Dietary Folic Acid Alters Metabolism of Multiple Vitamins in a CerS6- and Sex-Dependent Manner.

Moreover, TPP concentrations showed a modest increase with increase in FA in the diet in WT males only, although the changes did not reach statistical significance.

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The female mice also had high variability of vitamer concentrations but showed a clear trend for increased alpha-tocopherol in the WT mice on FS diet, as well as a statistically significant increase in the KO mice on FS compared with the Ctrl diet (2.5- and 6.8-fold correspondingly).

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The male mice displayed high variability in both FMN and FAD concentrations, and only the CerS6 KO brains showed a trend for increasing mean cofactor concentrations with increase in dietary FA, which is opposite to the effect observed in the liver.

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