Barely Significant
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Hyperpolarized <sup>13</sup>C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma-A Proof of Principle Study.

Cancers (Basel) · 2022 · PMC8773685 · PMID 35053497

Europe PMCDOI
4
hedged sentences
0.0520
closest p · 1.0× alpha
0.3000
boldest claim

The sentences

borderline significancep = 0.052so close (0.05 < p ≤ 0.1)
The k PL showed borderline significance in predicting the variance in tumor MCT1 expression at the biopsy level ( p = 0.052; Supplementary Figure S8 ) and was independent of the cell density in tumor biopsies ( p = 0.95, Supplementary Figure S7 ).

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showed a trendp = 0.30not close (p > 0.1)
The perfusion fraction showed a trend for correlation with the median k PL ( p = 0.30, r = −0.58; Figure 2 c).

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failed to reach statistical significanceno p-value reported
Comparison of 1 H-MRI parameters with WHO/ISUP tumor grade showed that perfusion fraction, a measure of capillary volume, trended towards a negative association with grade, but failed to reach statistical significance ( Supplementary Figure S3d ).

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did not reach statistical significanceno p-value reported
The perfusion fraction was most strongly associated with tumor grade, but this association was weaker than for k PL , and did not reach statistical significance.

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