L-Serine Supplementation Blunts Fasting-Induced Weight Regain by Increasing Brown Fat Thermogenesis.

A gene expression analysis of TNFα IL-6 and CD68 expression in SCF and PGF revealed a significant downregulation of TNFα and a strong trend toward reduced CD68 expression in the PGF of HFD-fed L-serine-supplemented mice compared to HFD-fed controls ( Figure S2e ).

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Similarly, L-serine supplementation showed a trend towards reduced EE in ad libitum HFD-fed mice versus an increase following an overnight fast ( Figure 4 a).

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We observed a similar trend in CD-fed mice, although the differences did not reach statistical significance.

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