Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models.

In contrast, associations between proteasome activity and total polyubiquitinated proteins did not reach statistical significance ( Fig. 3, K and O ).

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We also noted a negative trend between BACE1 protein levels and proteasome activity, but, similar to rodent studies, this trend failed to reach statistical significance ( Fig. 3, K and M ).

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We observed a nonsignificant trend toward reduced BACE1 levels with enhanced proteasome function (fig.

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