Minimized Extracorporeal Circulation Is Associated with Reduced Plasma Levels of Free-Circulating Mitochondrial DNA Compared to Conventional Cardiopulmonary Bypass: A Secondary Analysis of an Exploratory, Prospective, Interventional Study.

Although the single time point analyses showed a trend toward reduced mtDNA release, the level of statistical significance was not reached.

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Even though the amount of mtDNA tended to be lower in patients with MiECC, the difference with cCPB failed to reach statistical significance in the single time point analysis. 3.2.

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Even though, the EuroSCORE and other pre-existing diseases did not differ significantly between the study groups, the acute inflammatory state associated with myocardial infarctions might explain the preoperative elevation of mtDNA levels in the cCPB group (which, however, did not reach statistical significance).

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