Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen.

Although some clusters also showed a trend for decline in PI (C5, C6, C9, and C10), most did not (C1, C2, C3, C4, C7, and C8).

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As expansion of previously primed antigen-specific T cells may impact T cell responses to vaccination, we examined correlations across visits ( Figure 2 G) and found a significant association or a strong trend between CD4 + T cell responses at V0 and the post-first-dose time points V1 and V2, but not after the second dose.

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Several PI showed robust responses after the priming and boosting inoculations, although the increase did not reach statistical significance ( Figure 2 E).

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