Does the Combined Use of Aspirin and Immunotherapy Result in Better Outcomes in Non-Small Cell Lung Cancer Than Immunotherapy Alone?

Cureus · 2022 · PMC9190187 · PMID 35720783

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0900

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

Although the male gender had higher odds of having PD (AOR = 1.45), it did not reach statistical significance (p = 0.06).

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close to significancep = 0.06so close (0.05 < p ≤ 0.1)

Similarly, daily ASA use with PD-L1 inhibitors showed a trend toward achieving CR but only with a probability close to significance (AOR = 1.85, 95% CI 0.99-3.46, p = 0.06).

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failed to reach statistical significancep = 0.09so close (0.05 < p ≤ 0.1)

Pre-existing COPD (moderate to very severe) showed a trend toward an increased likelihood of survival at 18-months after diagnosis, but it failed to reach statistical significance (p = 0.09).

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showed a trendno p-value reported

ASA with PD-L1 inhibitor showed a trend towards a higher likelihood of achieving CR [adjusted odds ratio (AOR) 1.85] with a p-value close to statistical significance (0.06).

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