Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis.

Gene expression of Ly6G trended towards lower expression mainly in global- and myeloid-specific Nlrp3 knock-out mice, and to a lesser extent in hepatocyte-specific knock-out mice compared with control mice, although this did not reach statistical significance ( Figure 4 , C ).

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Hepatocyte-specific knock-out mice showed a strong trend towards lower pathologic collagen deposition, whereas HSC-specific knock-out mice did not show a difference in collagen deposition compared with control mice ( Figure 6 , A, C ).

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Hepatocyte-specific knock-out mice showed a trend towards a lower expression of α-SMA, whereas HSC-specific knock-out mice did not show a difference ( Figure 5 , A, C ).

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