Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation.

J Hematol Oncol · 2022 · PMC9442956 · PMID 36064577

Europe PMC DOI

hedged sentences

0.3500

closest p · 7.0× alpha

0.3500

boldest claim

The sentences

showed a trendp = 0.35not close (p > 0.1)

IDH1 mutational subclasses were associated with a trend toward better OS (R132C, HR = 0.86, p = 0.5; R132H, HR = 0.89, p = 0.6), whereas IDH2 R140 showed a trend toward inferior OS (HR = 1.1, p = 0.35).

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did not reach statistical significanceno p-value reported

Interaction analysis demonstrated a trend toward improved outcomes for the interaction of alloHCT and IDH1 R132C (OS, HR = 0.52, p = 0.15; RFS, HR = 0.64, p = 0.28) and IDH2 R172 (OS, HR = 0.31, p = 0.1; RFS, HR = 0.43, p = 0.15), although they did not reach statistical significance.

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a negative trendno p-value reported

Vice versa, a negative trend for survival was revealed in IDH mut patients compared with IDH WT patients when receiving chemo-consolidation only (Fig. 3 ).

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