Deregulation of complement components C4A and CSMD1 peripheral expression in first-episode psychosis and links to cognitive ability.

Eur Arch Psychiatry Clin Neurosci · 2022 · PMC9508018 · PMID 35532796

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hedged sentences

0.0670

closest p · 1.3× alpha

0.1320

boldest claim

The sentences

showed a trendp = 0.067so close (0.05 < p ≤ 0.1)

Female FEP cases showed a trend toward higher C4A expression levels compared to male cases (Mann–Whitney test p = 0.067), whereas the above association was not present in healthy participants (Mann–Whitney test p = 0.749).

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did not reach statistical significancep = 0.132not close (p > 0.1)

1 , we observed that C4A was marginally over-expressed in FEP cases; however, this difference did not reach statistical significance (one-sided Mann–Whitney test p = 0.132).

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nominally significantno p-value reported

In our sample, nominally significant associations were noted between C4A peripheral mRNA levels and PANSS general psychopathology as well as total symptoms severity, which corroborate prior evidence indicating a relationship between higher C4A expression levels in PBMCs and more severe psychotic symptomatology [ 21 ], albeit it should be stressed that our limited sample size could not permit definite conclusions.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.