The impact of pre-transplant donor specific antibodies on the outcome of kidney transplantation - Data from the Swiss transplant cohort study.

Front Immunol · 2022 · PMC9532952 · PMID 36211367

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showed a trendno p-value reported

Single DSA with a MFI of >2000 showed a trend towards faster decline of graft function as measured by mean total eGFR slope ( Figure 4G ).

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a slight trendno p-value reported

The mean MFI of the detected DSA did not significantly differ between the different HLA target loci, but there was a slight trend towards higher DSA against HLA-DQ ( Figure 1D ).

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a clear trendno p-value reported

did not reach statistical significanceno p-value reported

The mean total eGFR slope calculated over the complete follow-up (which reduces the effect of graft loss but does not capture temporal dynamics) showed a clear trend towards accelerated eGFR decline in patients with DSA, but this did not reach statistical significance ( Supplementary Figure 1D ).

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