Efficacy and Safety of Direct Oral Anticoagulants in Patients With Antiphospholipid Syndrome: A Systematic Review and Meta-Analysis.

Cureus · 2022 · PMC9587712 · PMID 36299971

Europe PMC DOI

hedged sentences

0.2200

closest p · 4.4× alpha

0.2200

boldest claim

The sentences

did not reach statistical significancep=0.22not close (p > 0.1)

The subgroup with double or isolated aPL also tended to develop increased risk; however, they did not reach statistical significance (RR 1.70, 95% CI 0.73-3.99; p=0.22; I 2 =0%; six studies) (Figure 4B ).

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failed to reach statistical significanceno p-value reported

showed a trendno p-value reported

The risk of all bleeding events showed a trend favoring DOACs but failed to reach statistical significance.

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