CIR dose-response investigations of male pilot MSC mortality in the ESCAPE and large German cohort failed to show clear evidence of an association between cumulative CIR dose and melanoma risk with only observations of non-significant positive estimates that did not exhibit a significant trend test across categories.
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flight attendant pilot aircrew cosmic ionizing radiation cancer aerospace military Smaller retrospective cohort studies have also yielded similar findings of associations or near-significant positive estimates with work as a female FA ( 28 , 29 , 34 , 37 , 43 ).
Studies evaluating brain/CNS cancer incidence in male pilots also lack a clear trend.