High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.

The ANOVA analysing the B6 and placebo group data revealed a highly significant reduction in anxiety at post‐test (F(1,173) = 10.03, p = 0.002, η p 2 = 0.055).

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Follow up t‐tests showed a trend towards a difference in the minimum amount of contrast that could be detected between the two groups when the surround was present (t(204) = −2.31, p = 0.057, d = −0.27), which was non‐significant when it was absent (t(204) = −1.35 p = 0.179, d = −0.19). 3.4.

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Instead, there was a tendency for depression scores to decrease between baseline and post‐test in the B6 group but to increase in the placebo group, and this interaction approached significance (F(1,96) = 3.08, p = 0.083, η p 2 = 0.031).

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B12 supplementation also produced an unexpected trend towards greater intrasubject reaction time variability.

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We found no clearly significant effects of Vitamin B12 supplementation on the outcome measures, although there was a suggestive trend towards reduced anxiety, and a trend towards an increase in visual contrast thresholds.

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