Donation type and the effect of pre-transplant donor specific antibodies - Data from the Swiss Transplant Cohort Study.

A further analysis including patients with a cumulative DSA MFI of <1000 showed a trend for better outcome in DCD transplants ( Supplementary Figures 5A–D ).

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A similar trend could be observed for both LD and DCD transplants but this did not reach statistical significance possibly due to the low number of DSA positive transplants with extended cold ischemia time ( Figures 6E, F ).

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In terms of graft loss, all of the DSA positive patients regardless of donation type showed very similar death censored graft survival ( Figure 4C ), with a slight trend towards inferior graft survival in DSA positive DCD recipients beyond 5 years, but this was based on very few patients and did not reach significance.

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Recipients of DBD grafts with DSA also showed a significantly decreased graft survival whereas there was a strong trend towards increased graft loss in DSA positive DCD recipients without reaching statistical significance, likely due to the smaller number of patients within this group ( Figures 3D, F and Table 2 ).

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