Excerpts

12/15 studies (80%) reported significantly higher CXCL10 levels in vitiligo patients compared to controls, resulting in an overall highly significant CXCL10 concentration in the blood of vitiligo patients (P < 0.00001) ( 13 – 20 , 22 , 23 , 25 – 28 ).

The network is visualized using Cytoscape5, where the activation of both innate and adaptive immunity was significantly enriched in postintervention PB ( Figure 3B , colored by cluster pathway; Figure 3C , list of top 20 enriched pathways with highly significant P -values ( P < 0.00001) for PB with TRT versus no treatment).

At a general hospital level, Hellgren et al., retrospectively analyzing data from 83 patients with RRMS, PPMS, and SPMS, reported a highly significant reduction of ARR induced by rituximab (500 or 1,000 mg every 6–12 months) from mean 0.38 ± 0.5 before treatment initiation to mean 0.05 ± 0.19 at follow-up (p<0.00001), with a global reduction by 87% ( 82 ).

Our study therefore demonstrated highly significant ( p < 0.00001) recovery of a VH3-enriched set of B cells and our findings therefore confirmed the selection of SpA-binding switched post-germinal center B cells that was solely based on the VH region and was apparently not affected by light chain usage.

none of the fertile controls, a highly significant difference (P<0.00001).

In a European patient cohort study of 110 candidate polymorphisms, Hhex SNP rs1111875, a major risk factor in T2D, was found to be a highly significant risk factor (p<0.00001) for AD, but only with the accompanying GSTM3 (rs7483) SNP ( 171 ).

The analysis revealed strong, highly significant LD (p < 0.00001) between HLA-A and the Class I loci HLA-C and the Class II loci HLA-DRB-1.

SNP Selection and Genotyping According to the results of GWAS, six highly significant variants ( P < 1 × 10 −5 ) were selected for further validation.

MSC-induced enhancement of AML cell proliferation in transwell cocultures was highly significant also when analyzing the overall results for this larger group of patients (Figure 2 A; p < 0.00001, Wilcoxon’s signed-rank test).

All of the top 20 biological process pathways of the primary analysis ( Figure 1D , left panel) remained highly significant (adj p<0.00001).

The results indicated that the assumption that, for all the cytokines evaluated, irradiation with Fe ions causes an increase in the levels of each of the cytokine evaluated that is highly significant (p value < 0,00001).

We mapped the regional presentation score of the most highly represented protein in the neuroblastoma ligandome, NPY (29 MHC Class I peptides detected in 16 neuroblastomas), finding a highly significant concordance between the empirically detected peptides and those regions of the protein expected to be highly presented ( Figure 3E ; p = 0.000011), and find no peptides in the ligandome derived from the signal peptide region (aa 1–28) which is cleaved from the full-length pro-NPY protein.

Survival analysis based on the model risk score demonstrated a highly significant difference (P = 1.363e-05) in the training cohort ( Figure 6C ).

Histopathological findings across MVI cohort A highly significant association was observed between microvascular inflammation and C4d positivity (p=0.000029).

After repacking of modeled structures, which led to structural fitting of contacting residues and displacement of their side-chain groups, the correlations of steric descriptors became weaker, while the correlations of hydrophobic descriptors still remained highly significant (p-value = 6x10 -5 ). 3.4 Identifying residue binding features in CDR3: peptide interface using machine learning At the final stage we performed RFE (Recursive Feature Elimination) analysis and applied the Random Forest (RF) algorithm to make predictive models for the per-residue contacting energy values for amino acid residue pairs in CDR3 loops and peptides.

The model demonstrated strong predictive performance (AIC = 679.94, concordance index = 0.84) with a highly significant global log-rank p-value (p = 7.07 × 10 -5 ).

On the single-cell secretion levels ( Figure 2A , 2 nd panel), the secretion rate distributions showed a highly significant difference for 1-, 12- and 24-hours of stimulation (p < 0.0001 for all) and resolved to a slight difference for the 36-hour stimulation (p = 0.04).

Bath-vaccinated cod displayed complete protection following Va -O2a challenge, whereas naïve fish showed ~50% survival, a highly significant difference (log-rank test p < 0.0001).

The prevalence of these patterns in the elderly group was highly significant when compared to the prevalence in the group under 60 years old (n=926) (χ2 = 35.9, df=1, p <.0001).

Analysis of spectra counts showed a highly significant elevation of immunoglobulins in MS CSF ( Figures 5B , ANOVA p < 0.0001).

Validation and multi-omics characterization of the RSF-based prognostic model Using the RSF-based prognostic model, patients in the TCGA training cohort were stratified into high- and low-risk groups with a highly significant difference in overall survival (P < 0.0001, Figure 4A ).

In addition, in an in vivo experiment including the treatment of non-targeting PG CAR-IL15 T cells, no significant body weight loss was seen in the mice of this group, although we indeed observed a trend toward slower tumor growth in those treated mice from Day 18 after treatment, which did not reach statistical significance (mean tumor volume on Day 21: 39.5 vs 454.1 or 301.7 mm 3 for H9 CAR-IL15 vs UN-T or PG CAR-IL15, p < 0.0001; Figure S4F ); this observation is possibly explained by the fact that IL-15 itself produced from non-activated CAR-T cells may induce the antitumor activity when it accumulates to a certain level, which is consistent with previous studies showing that IL-15 has modest anticancer activity as a single agent ( 24 ).

After adjusting for all covariates, PHQ-9 scores were positively and linearly associated with CVD risk; a highly significant nonlinearity was observed ( p < 0.0001).

It was found by flow analyses ( Figure 7B ) that NAV-duplexes were strongly recognized by IgG1-DS5 on biotin-labeled cells, with no such signals arising from NAV alone [highly significant by t -test analysis (Methods); p <0.0001].

Furthermore, a highly significant reduction was noted in IL-17-expressing cells across all three probiotic groups (DCF0420 P < 0.0001; DCF0514 P = 0.0001; DCF0620 P < 0.0001) compared to untreated colitis controls.