Barely Significant

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The more recent the year at index mammogram, the higher the adjusted rate ratio of breast cancer for women with benign breast disease compared with women without benign breast disease, with the highest risk observed among those with index mammogram in 2011 to 2015 (RR = 3.11, 95% CI: 2.41 to 4.03) with a significant trend across calendar periods ( p -trend < 0.05) ( Figure 3 ).
A significant trend was observed in two UK studies, reporting an annual increase of 5% between 1998 and 2010 [ 6 ] and of 78% in 2012 compared with the year 2000 [ 11 ]; in Spain [ 12 ], the incidence significantly increased from 3.82 per 100,000 in 2004 to 6.98 in 2013; in Sweden, the incidence of IPF ranged from 10.4 to 15.4 cases per 100,000 population per year between 2001 and 2015 [ 22 ].
Finally, relevant data concerning other sleep disorders (e.g., obstructive sleep apnea, circadian rhythm disorders, and nightmares); health-relevant behaviors, such as substance misuse and the use of electronic devices; and specific psychological variables, such as resilience and coping, have not been gathered in our study, despite their role in the relationship between sleep and well-being, which is likely to be significant [ 24 , 72 , 73 , 74 ].
Except for one small single-intervention study among older adults, which showed a small but significant increase in body weight [ 56 ], the remainder of the studies among adults consistently reported no statistically or practically significant changes in body weight and composition as a result of adding hazelnuts to the diet.