Barely Significant

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Inconsistent fluctuation in drug concentration has been recognized as a highly significant challenge of conventional oral drug formulations for sustained and safe therapeutic effects of drugs.
Microfabrication for Drug Delivery.
Materials (Basel) · 2016 · PMC5509096
[ 66 ] observed an increase in the notched Izod impact energy ( Figure 15 ) from a glass bead content of 10 vol.% with no influence of the surface treatment and found also an increasing trend with several particle sizes ( Figure 16 ) [ 67 ], explained on the basis that when glass bead filled PP composites receive an impact force, the beads will induce crazes in the matrix around the surface because of stress concentration and will increase surface area to absorb the impact fracture energy.
For example, with a variation of the functional groups at the surfaces of UiO-66(Zr), UiO-66(Zr)-NH 2 and UiO-66(Zr)-2COOH, their adsorption performances demonstrate an increasing trend, probably resulting from the more favorable formation of acid-base or/and hydrogen-bond interactions between UiO-66(Zr)-2COOH and verapamil than those from UiO-66(Zr) and UiO-66(Zr)-NH 2 .