Excerpts

Diclofenac sodium exhibited consistently low percentages of edema across all time points with highly significant reductions ( p < 0.001) compared to the control.

The elicited antibody response of mice as illustrated in Figure 4 showed a highly significant ( p value < 0.001) increase in O.D reading of SARS-CoV-2 inactivated group in comparison with control group and peptides groups at weeks 2, 4, 8 and 10 post-vaccination.

In this line, the contractile response to PE was tested and both compounds significantly reduced the contractile response to PE, although oxime–1 showed a more highly significant ( p < 0.001) reduction of the contractile response to different concentrations of PE (10 −7 to 10 −5 M).

After post hoc testing, the following significance levels were specified: extremely significant ( p < 0.001), highly significant ( p < 0.01), significant ( p < 0.05), and not significant ( p > 0.05).

A value of p < 0.05 was considered statistically significant, p < 0.01 was considered statistically highly significant and p < 0.001 was considered statistically extremely significant. 3.

It could be observed that the coefficients of X 1 , X 1 X 3 , X 1 2 , were highly significant ( p < 0.001).

The results from ANOVA showed that the effect of genotype factor on pigment contents was highly significant ( p < 0.001) ( Table 3 ).

Wound-healing was slowest in untreated group (A), showing the maximum diameter throughout the study period with wound closure 17.56% and 50.44% on day 5 and 10, respectively, while Group D, treated with commercial product, showed maximum healing of 49.1% and 95.3%, as shown in Figure 9 , which showed highly significant ( p < 0.001) results when compared to untreated groups, whereas Group C, treated with the CEO NFs, also showed better healing percentage (45.41 and 90.13) on the 5th and 10th day of treatment, which is more significantly different ( p < 0.01) from Group A, but less than that of the commercial product, as shown in Table 4 .

The ANOVA of the quadratic regression model demonstrated that the model was highly significant, as was evident from a very low probability value ( p = 0.001).

For the DPPH, Folin–Ciocalteu and CV methods, one-way ANOVA revealed highly significant differences among oils (all p < 0.001).

To confirm the previously obtained values, an analysis of variance (ANOVA) test was first conducted ( Table S3; Supplementary Materials ), with significance values less than 0.05 and showed highly significant differences across all treatments ( p < 0.001).

Nevertheless, in this case, the effect was not significant ( p < 0,05) only in young worms (day 2) at 200 μM, while it is highly significant ( p < 0.001) at 300 μM and in adults in post-reproductive stage (day 9), with respect to controls reproductive stage (day 9), with respect to controls.

The 5–50 mg/kg doses of ME showed a highly significant reduction of the paw edema at 2, 4, and 6 h after the initiation of edema compared with the control ( p < 0.001).

A one-way ANOVA test applied on the concentrations values of the identified compounds listed in Table 1 showed that there is a highly significant difference between these three extracts ( p < 0.001). 2.2.

Each group was individually compared with the positive control and the statistical differences were shown, as follows: *: significant ( p < 0.05); **: highly significant ( p < 0.01); ***: extremely significant ( p < 0.001); and, ns: non-significant ( p > 0.05).

A highly significant difference in anti-VZV activity was observed between the purified flavonoid extract and the fresh juice group ( p < 0.001).

The following final regression Equation (1) for production of total minor ginsenosides ( Y 9 ) was obtained in terms of coded factors: Y = 92.8 − 2.16 X 1 + 5.82 X 2 + 2.46 X 3 − 9.79 X 1 X 2 + 3.45 X 1 X 3 − 0.88 X 2 X 3 − 26.25 X 1 2 − 46.02 X 2 2 − 17.31 X 3 2 (1) The ANOVA results ( Table 3 ) showed that the total model for production of the minor ginsenosides ( Y 1 – Y 9 ) was highly significant, with a p value of <0.001, while the lack of fit is not significant relative to the pure error, with a p value of >0.05.

Both the PI3K inhibitor GDC0941 and the mTORC1 inhibitor rapamycin caused a highly significant inhibition of AML cell proliferation when analyzing the overall results ( Table 1 , p < 0.001).

For CBZ, the same factors were also highly significant (F(1, 12) = 789.29, F(2, 12) = 909.18, F(2, 12) = 335.61; p < 0.001).

Specifically, the sampling period exerted a highly significant ( p < 0.001) main effect on the extracts, density, and refractive index ( Table 2 ).

Statistical analysis revealed that the sample factor exerted a highly significant influence ( p < 0.001) on all quantified fatty acids ( Table 2 ), with partial eta squared values ranging from 0.794 to 0.993, underscoring the dominant contribution of biological variability to hempseed lipid composition.

The Mann–Whitney U test confirmed that this decrease was highly significant ( p < 0.001). 2.7.

Not surprisingly, this correlogram showed a strong and highly significant ( p < 0.001) correlation between silymarin content and the in vitro antioxidant assays CUPRAC (PCC = 0.92) and FRAP (PCC = 0.91).

The highest level was observed in the 40% combination group (CDDP 11.2 μM + ε-VNF 8.4 μM), reaching 4.3 ± 0.6 μM, which was found to be highly significant (*** p < 0.001).

Pearson’s correlation of the higher level of confidence ( p < 0.05 was significant, p < 0.001 was highly significant) was evaluated in the relationship between variables.