Excerpts

6c ) Stratified by 30-day survival, we found a highly significant correlation between LRT neutrophil elastase and galectin-3 in survivors only (Fig. 6d, r = 0.54, p < 0.0001), an effect that was also driven primarily by patients with ARDS, as well as patients classified to the hypoinflammatory subphenotype (Fig. 6e–f ).

En masse , there were highly significant differences between the mutation spectra before and after chemotherapy ( P <0.0001, χ 2 test, Supplementary Fig. 10 ).

Among the 12 loci associated with MG in the European meta GWAS, we identified nominally significant associations with same directional effects in the CTLA4 at 2q33 (rs231779, OR = 1.17, P = 1.0 × 10 −4 ), FAM76B at chromosome 11q21 (rs4409785, OR = 1.17, P = 0.030), and TNFRSF11A regions at 18q21 (rs7239261, OR = 1.14, P = 1.3 × 10 −3 ) in Japanese (Supplementary Table 2 ).

A positive da value was highly significant ( t = 21.463, p < 0.0001), showing a higher response in antibody level for the vaccinated group (~16x higher scaling response, a control ~ 0.03; a vaccinated = a control + da ~ 0.52), and a higher antibody level over time following vaccination.

Considering the set of GO terms that are highly significant in snRNA-seq (adjusted p -value < 0.0001), 42 out of 47 GO terms identified that were also significant in proteomics (adjusted p -value < 0.05) had the same direction of up/down-regulation.

The model was highly significant ( P < 0.0001) and showed an improved R 2 m of 0.3180 (Fig. 4 , right; Supplementary Table 6a ), supporting an immunometabolic contribution to clinical severity within EBV-naïve/low participants.

This two- to three-fold enrichment for HGT C was highly significant (binomial GLM, estimate = 1.18, SE = 0.07, P < 0.0001; Fig. 2 ; Supplementary Table 3 ) in both species at both timepoints.

The highly significant correlation ( r =0.81, n =59, P <0.0001) between the Qamdo and regional residual series indicates the representativeness of the station record for larger spatial scales.

Stretching resulted in a more moderate yet highly significant increase in γH2Ax-positive nuclei both in leiomyoma and myometrium cells (OR = 1.6 and P < 0.0001; Fig. 4d and Supplementary Fig. 12 ).

Individually, HiFiCas9 treatment had a highly significant impact on viability (F (1, 12) = 69.55, p < 0.0001), accounting for 72.96% of the total variance.

3c ), highly significant effects in paired two-way t tests (weakest effect: p = 0.0001), indicating that our experimental conditions do give rise to the so-called stereo-movement suppression phenomenon.

There are also highly significant associations with measures of nuclear grade including nuclear membrane irregularity, ( p < 0.0001), nuclear size ( p < 0.0001) and nucleolar size ( p < 0.0001) (Fig. 5d ) and with high-risk histological patterns of disease (Fig. 5e ).

A weaker association was identified in LG7, where 15 SNPs exceeded a threshold suggestive of significance ( p < 0.0001) (the location of the SNPs highly associated with sex that exceed the thresholds are shown in Supplementary Data 2 ).

Differences considered significant when p < 0.05 (*), very significant when p < 0.01 (**), highly significant when p < 0.001 (***), and extremely significant when p < 0.0001 (****).

This is a highly significant difference compared to metagenomes from individuals from other countries from which bacteroidetocin B was detected in 1.9–6% of metagenomes ( P < 0.0001).

We found highly significant positive correlations ( r > 0.91, p < 0.0001, n = 324) between the fragment intensities of all samples and only very minor and non-significant deviations from a slope of one, with Δsl ranging from 0.008 (NADW/EMW) to up to 0.243 (Lake/AABW) (Fig. 2 ).

All these differences were highly significant (pairwise two-tailed t-tests, P<0.0001).

A two-way mixed-design ANOVA with the fixed factors of ‘electrode group’ and ‘recalled category’ and the random factors of ‘patient’ and ‘electrode’ (see Methods section for further details), revealed a highly significant interaction (F(1,63) = 17.69, p < 0.0001), indicating that each group of electrodes increased its HFB amplitude when the patients tried to recall images from its preferred category (Fig. 3a ).

A linear regression analysis showed a very good correlation ( R 2 = 0.924) between the HrOr263 hydrocarbon responses in the ab3A and ab2A neurons, which was highly significant ( p < 0.0001).

The main frequency effect was highly significant ( F 3,24 = 41.10, P < 0.0001).

This distribution of alternative and constitutive pG4 genes for each UTR context was found to be highly significant through permutation testing ( P value < 0.0001 for 5′ and 3′ UTRs).

pistillata corals remained highly significant when comparing across treatments and sites ( p < 0.0001) (Fig. 2E ).

In spite of some discrepancies, as mentioned earlier, the correlation between these two parameters was highly significant (Pearson correlation coefficient, r = 0.8104, p < 0.0001) (Fig. 8 ).

Additional association analyses of LCN2 and MMSE scores including all groups with cerebrovascular disease (SVDND, VCIND, and VaD) showed highly significant negative correlations in cohort 1 (cc = −0.55, p < 0.0001, Fig. 3c , Spearman correlation test) and cohort 4 (cc = −0.56, p = 0.008, Fig. 3d , Spearman correlation test).

Such a non-uniform distribution is highly significant ( P <0.0001, Fisher exact test (75, 151; 204, 22)).