Excerpts

The results were considered significant at P < 0.05 (*), very significant at P < 0.01 (**), and extremely significant at P < 0.001 (***).

Faecal pellets of high dose krill collected at 4 and 24 h on the last day of exposure clearly show an increasing trend of whole beads being egested over the final 24 h ( X 2 1 = 238, ( N = 24828), p < 0.001) (Fig. 2 ).

Statistical analysis showed that the increase in NOX4 expression in PDAC patients is highly significant ( P <0.001) ( Fig. 2f ).

Differences were regarded as statistically significant and as statistically highly significant if p values were <0.05, and p < 0.001, respectively.

We found a highly significant, positive interaction (p < 0.001) effect between MAPK-pathway altered diffuse low-grade gliomas relative and clusters 1 and 2 (Fig. 3F , Supplementary Fig. 4 ), indicating over-representation of tumors with a higher expression of immune infiltrate-related genes with this tumor entity.

By performing sensitive sequence analysis using the generalized profile method 12 , we found this structural similarity to be mirrored by a distant but highly significant sequence relationship ( p < 0.001) between these families.

P ‐values were calculated, and statistical significance was reported as highly significant with *** P < 0.001.

Differences were considered statistically significant at *P < 0.05, very significant at ** P < 0.01, and extremely significant at *** P < 0.001.

Statistical significance was defined as significant ( p < 0.05), very significant ( p < 0.01) and highly significant ( p < 0.001).

Further stratification of patients into asymptomatic, mild, moderate, and severe infections highlighted an increasing trend in viral load concentrations (Fig. 2B , right), with significant differences in median viral loads overall across all severity levels ( P < 0.001 by Kruskal-Wallis H test).

9 ; PC 1 is correlated with centroid size r = 0.73 and frontal size explains approximately 32% of shape variance and is highly significant [adjusted R-squared = 0.33, degrees of freedom = 75, F = 37.11, P < 0.001]).

In the SPG, the dAl closely followed the change in surface ε Nd , showing a highly significant positive correlation (n = 19, R 2 = 0.88, p < 0.001, Fig. 6c ).

Further M1 and M2 macrophages enrichment analysis revealed a highly significant inflammatory M1 macrophages predominance in CCR-associated EOI samples ( P < 0.001) and significant M2 macrophages enrichment in relapse-associated EOI samples ( P < 0.05) (Fig. 7d ).

Data from six animals revealed mean peak MRI signal changes of 5.3±0.9% during wtCGRP injection, compared with changes of 1.2±0.1% during injection of aCSF alone; the difference between wtCGRP and vehicle was highly significant ( t -test P =0.001).

Despite the generally low levels of genetic differentiation, the populations exhibit a highly significant signal of isolation-by-distance (Mantel test r = 0.79, p < 0.001) which becomes especially apparent due to the large geographical extent of our sampling (Fig. 2d ).

In immortalized lymphocytes from human blood samples ( Supplementary Table 1 ), we observed a highly significant correlation between ARHGAP33 and SORT1 expression levels ( Fig. 7d ; r =0.42, P <0.001), suggesting that common cellular mechanisms regulate the expression of ARHGAP33 and SORT1 .

The bias towards the shortest chromosomes is highly significant, P = 0.001.

ITA values had a highly significant difference between pigmented and non-pigmented patches ( p < 0.001, linear mixed effects model; Fig. 4C ).

We additionally verified that the observed correlation was highly significant by permuting gene labels in the ABC dataset ( p value < 0.001 over 1000 permutations).

An example of a highly significant d-colocalized pair is THBS1-COL5A1 , which appears as a proximal pair (PP test p-value < 0.001, at d = 4 μm) in ~67% of the 3,147 cells where both genes were detected (Supplementary Fig. 3 ).

Using the categorization based on the three criteria, a highly significant percentage of the CNO-treated mice (50.0%) was considered addicted as compared to the control animals (16.7%, chi-square, P < 0.001, Fig. 3l ).

4C becoming highly significant (both increasing vs increasing-decreasing p = 0.001; both increasing vs other p = 0.013; both decreasing vs increasing-decreasing p < 0.001; both decreasing vs other p < 0.001; LME post-hoc tests, Tukey correction), as well as the difference between increasing-decreasing and other pairs becoming significant ( p = 0.040).

The quantitative data confirmed the previous qualitative observation in revealing a highly significant increased incidence of Type 1 cells in Cyfip1 +/− (LME: χ 2 (1) = 68.49, p < 0.001, Fig. 4c ).

The frequency of several of these latent interactions were highly significant above the empirical distribution of the population of detected ligation junctions ( p < 0.001) (Table 2 outlier test, part A).

We removed SNPs from the meta-analysis if they exhibited highly significant heterogeneity across studies (Cochran Q I 2 P -value ≤ 0.001), or co-located with CpG from the DNAm age predictors according to the Illumina annotation file for the Illumina Infinium 450K array.