Excerpts

coli genes (Supplementary Table 4 ), a highly significant dependence of functionality on phylogenetic distance for cell-interacting proteins (Mann–Whitney U -test, P < 0.001), but no change for drug-interacting resistance mediators (Mann–Whitney U -test, P = 0.57), was observed.

Data from six animals revealed mean peak MRI signal changes of 5.3±0.9% during wtCGRP injection, compared with changes of 1.2±0.1% during injection of aCSF alone; the difference between wtCGRP and vehicle was highly significant ( t -test P =0.001).

By contrast, the global OH abundance in the SSP370 scenario exhibits a decreasing trend of 0.037‒0.15% yr −1 ( P < 0.001) over 2015‒2100 among these models, together with an increase in tropospheric O 3 of 0.11‒0.17% yr −1 ( P < 0.001) (Supplementary Figs. 3 and 4 ).

When whole-body imaging data was included into the analysis we identified a highly significant positive correlation between the maximum size of the biopsied FLs with the proportion of unshared mutations (Spearman’s correlation ρ = 0.62, P < 0.001).

There was a highly significant tendency of the BV-positive samples to sort to the polymicrobial clade and BV negative samples to the Lactobacillus clade based on either the Amsel ( p < 0.001) or Nugent BV diagnosis ( p < 0.001).

Supporting the notion of trait-like stability in sAA, we observed highly significant medium- and large-sized correlations in baseline sAA between the 3 days (day 1–2: R(51) = 0.46, p < 0.001; day 1–3: R(51) = 0.61, p < 0.001; day 2–3: R(51) = 0.60, p < 0.001; n = 53; Supplementary Fig. 4a–c ).

ITA values had a highly significant difference between pigmented and non-pigmented patches ( p < 0.001, linear mixed effects model; Fig. 4C ).

Between lactation days 1 to 15 there was a highly significant effect of day of lactation (RM GLM F = 35.18, P < 0.001) as well as a significant effect of diet ( F = 5.134, P = 0.041) on maternal gross FI.

Results indicated that the number of TP mutations detected by o2n-seq were extremely significant (all P <0.001, Student's t -test) more than that of Cir-seq for any CSs criteria (1 × −5 × ) ( Supplementary Fig. 4a ).

When compared to the 3373 common targets of three B-ARRs, the percentage of overlap dropped to 35.4% which is still highly significant (Fig. 4b ; Fisher’s Exact Test p < 0.001).

These effects are marginally significant ( P = 0.095), but the genetic effects due to differences among four QTL genotype combinations C/C, C/T, T/C, and T/T are highly significant for both species ( P < 0.001) (Fig. 4a ).

The normalization procedure yields a statistically highly significant correlation (adjusted R 2 = 0.68 with p value <0.001), thus supporting our hypothesized exponential relationship between MAR at a certain location in the fjord, relative to both the core location’s distance to the margin of the most productive glacier and to the surface runoff from the glacier catc

Specifically for Northern Europe, there is a marginally significant ( P =0.06) warming despite a highly significant ( P <0.001) decrease in zonal wind ( Table 1 ), the latter implying a more easterly flow regime typically linked to colder winter temperatures.

The models considering upstream deforestation within 30 km of the sampling sites were highly significant ( p < 0.001) and explained >22% of the model variance (Fig. 3 , Supplementary Table 1 , see Supplementary Fig. 1 for model validity assessment based on residual distributions).

Although no parity history was available on these publicly available cases, upon applying our PPBC gene signature to this YWBC cohort ( n = 311 patients with both ER+ and ER− disease) we observed a highly significant decrease in 15-year overall survival in breast cancer patients with a PPBC Hi signature score (HR 2.134, p = 0.0011) compared with those with a low score (PPBC Lo, Fig. 5f ).

ARRDC2 , located in the cytoplasmic vesicle and plasma membrane and predicted to be involved in protein transport 28 , showed a highly significant positive linear correlation to lesion growth rate ( R = 0.99, p = 0.0011) (Fig. 3 ).

P mass was highly significant in the model ( P = 0.00129), indicating different J max – V cmax relationships with leaf P mass .

4a ), and combining both markers yielded a highly significant association with worse overall survival ( P = 0.0013) (Supplementary Fig. 4b, c ).

The sentinel SNP nearby UMOD from our study (rs77924615) is a nominally significant eQTL within NephQTL 76 (a database of nephrotic syndrome human kidneys) in the kidney tubules ( p = 0.0014) and has a non-significant effect in the glomerulus ( p = 0.079).

SLCO1B1 locus was nominally significant in the UKBB ( p -value = 1.84e−03) and genome-wide significant in the TC response GWAS for which sample size was larger ( p -value = 1.89E−09, baseline adjusted).

2a ), leading to highly significant two pairs of negative correlations between SALL4 and miR-200c ( P = 0.002, R = -0.3157, Pearson’s correlation coefficients) or miR-200c and PD-L1 ( P = 0.0007, R = -0.3469, Pearson’s correlation coefficients), accompanied with a positive correlation between SALL4 and PD-L1 expression ( P < 0.0001, R = 0.3773, Pearson’s correlation coefficients) (Fig. 2b ); however, no statistical correlation among these molecules was identified in peritumor regions ( P = 0.2441, R = 0.0771; P = 0.2927, R = 0.0604; P = 0.3921, R = 0.0292, Pearson’s correlation coefficients) (Fig. 2c, d ).

However, we found highly significant differences between age classes, such that juvenile snakes had higher reflectance than adults in all comparisons (all F > 10.77; p < 0.002; Fig. 3b, c , Supplementary Fig.

Nevertheless, the difference in decrease between the LSTAs showing ON and OFF polarity is highly significant ( p = 2 × 10 −3 , Fisher exact test).

Correlation analysis showed that among mice that reached the learning criterion in the cue discrimination task, there was a highly significant ( p = 0.002) correlation, when data from centromedial and centrolateral sites were combined, between learning index and the difference in area under the curve (AUC) of the dopamine responses to reward-predicting and non-reward-predicting cues (Fig. 5c ).

Amongst these, ten corresponded to HERVs, of which nine were Bonferroni significant features in the analysis comprising the full cohort (Bonferroni P < 0.05), whereas the tenth feature was only nominally significant (HERVL18_6p22.1c, TWAS P = 0.002).