Excerpts

Univariate analysis yielded highly significant differences among all tumors in RFS ( P = 0.0016) and OS ( P <0.0015) ( Fig 4A & 4B ).

Plants inoculated with fungi from all elevations showed a positive trend at three months with respect to nitrogen absorption and plant biomass respectively (F = 4.44, df = 1, p = 1.69x10 -3 ; F = 5.47, df = 1, p = 5.61x10 -6 ).

The difference in the median number of presentations between these two time periods was highly significant (post-GBS median = 16, interquartile range (IQR): 10–26; pre-GBS median = 10, IQR: 4–11, Wilcoxon signed-rank z = 3.13, p = 0.0017).

The pseudo-absence selection method had a highly significant (ANOVA, p = 0.0017) effect on model mean AUC values, but the interaction between model type and selection method was insignificant.

There was a highly significant difference in CN between the three conditions tested for all samples (Friedman test p = 0.0017 for EIF2C1 and 0.0046 for TSC2 ), with a significant pairwise difference between the original and Puregene CN values after Dunn’s multiple comparison correction (p = 0.0045 and 0.0141 respectively).

In addition, mean differences between the three rank groups were highly significant for blue-red contrast residuals (Kruskal-Wallis χ 2 = 12.5, p = 0.0018) while being not significant for blue saturation residuals (KW χ 2 = 5.68, p = 0.058) and for red saturation residuals (Kruskal-Wallis χ 2 = 5.45, p = 0.065), although both are close to significance.

More importantly, the slope of the concentration-effect line was steeper for the thalamus than for the cortex for all frequency bands and the differences were highly significant (p < 0.0018 for the 126–200 Hz range; p < 0.0001 for the other bands.

The difference between the rank totals of 30.1 (transparent) and 18.9 (opaque) is highly significant, H(1) = 9.606, p = .0019, ω2 = .184.

In the Boxers we do, despite the small sample size (n = 15), observe a nominally significant (p = 0.0019) association to fructosamine levels at the CFA3 locus which agrees with the epistatic pattern we observe between these two loci.

In the moderate and high corrected survival categories, regressions were highly significant (moderate: F 1,5 = 35.51, p = 0.0019; high: F = 9.43, p = 0.0078).

In LIS, we found a highly significant difference in salinity between restricted vs. reference sites (p = 0.0019; t 40 = 3.33), but not for temperature (p = 0.1588; t 40 = −1.44) or dissolved oxygen (p = 0.3821; t 40 = −0.88), which also mirrored results in the GOM (salinity: p<0.0001, t 40 = 11.89; temperature: p = 0.1409, t 40 = −1.50; dissolved oxygen: p = 0.2253, t 40 = −1.23; Table 2 ).

There was also highly significant difference in the occurrence of hearing loss between those three groups (Pearson Chi-square, p = 0.00193).

We then tested the association of target genes belonging to these pathways with PD risk, and identified nine SNPs in USP37 consistently associated with PD susceptibility in three genome-wide association studies (GWAS) datasets (0.46≤OR≤0.63) and highly significant in the meta-dataset (3.36×10 −4 <p<1.94×10 −3 ).

Three SNP in this significantly associated cluster at a distance of 118–121 Kbp from CUBN had significant test statistics (−log 10 ( P -value) = 3.1), while two SNP in CUBN had test statistics that were close to significance (−log 10 ( P -value) = 2.7).

The linear trend for all four groups was highly significant (R 2 = 0.48, p = 0.002).

Correlations with the Frontal Behavioural Inventory In the linear regression model with the FBI 12-22 of the combined patient cohort as the dependent variable, a statistically highly significant effect was seen for the right UF (adjusted R 2 = 0.44, unstandardized B = -116 [95% CI -182, -50], p = 0.002), left UF (adjusted R 2 = 0.319, B = -98 [95% CI -167, -29], p = 0.008), the right aCi (adjusted R 2 = 0.23, B = -56 [95% CI -105, -7.6], p = 0.026) and forceps minor (adjusted R 2 = 0.26, B = -77, [95% CI -139, -14], p = 0.019) ( Fig 4 ).

The MANOVA revealed a highly significant interaction term of fish density and resource effect on total cladoceran abundance (F 4,27 = 5.634, p = 0.002).

90 minutes of exposure to UV light resulted in a highly significant (p<0.002, n = 20) increase of gross O 2 production in the Ageladine A treatments vs. the controls (2.34 ± 0.38 and 0.92 ± 0.32% h -1 , respectively; Fig 1b ).

More importantly, the interaction between category and attribute was highly significant, F (1, 22) = 12.76, p = .002, partial η 2 = 0.37.

Overall, the difference between employed and unemployed candidates on the interview measure was highly significant d = .274(.094, .459), Z = 2.912, p = .002, one-tailed.

Furthermore, the plasma triglycerides-to-HDL ratio, a known marker for metabolic syndrome and highly atherogenic dyslipidemia,[ 18 ] showed a highly significant correlation with mFD (r = 0.480, p = 0.002).

Importantly, the three-way interaction effect was highly significant (F(1,13) = 15.606, p = .002, η 2 = .546), indicating that the difference between successive and non-successive trials was larger for 90 msec trials than for 30 msec trials.

In addition, we found that patients with high levels of C9orf86 expression showed a significant trend towards worse survival compared to patients with low C9orf86 expression (P = 0.002).

When analyzing the 15-year survival by including this variable, a highly significant negative prediction of the 15-year survival was obtained among the HNSCC patients ( P = 0.002) ( Fig 4 ).

The results of that analysis, shown in Figure 3 , confirm that degree of perturbation was more difficult to distinguish for some PL animations compared to others, but the pattern of results was the same for healthy controls and patients, with the correlation between groups being highly significant (r = 0.85, p = 0.002).