Excerpts

As discussed in Results , the identification of 10 of 54 genes with a link to HIV-1 replication is a highly significant over-representation (p value<0.00021) over the expected number (2.4) in randomly generated lists of 54 genes that are expressed in both Jurkat and MM6 cells.

Among them, rs1408705 (with borderline significance, p = 0.00024) is located in PACRG (PARK2 co-regulated), which was previously found to be deleted in clear-cell renal cell carcinomas [ 38 ].

A highly significant association with Gleason score was observed when the data was combined from these three studies with an Odds Ratio (OR) of 0.85 (95% CI = 0.77–0.93; p = 2.7×10 −4 ).

3M ) revealed a highly significant reduction (48±19%) in the number of GluA4 clusters in the OPL of GluA4fl/fl:Cx57+/Cre mice (p = 2.9×10 −4 ).

Overall, the interaction between origin and resource chosen was highly significant (factorial ANOVA, F 1, 32 = 16.6, P = 0.00029: Figure 1 ).

When the analysis was performed using only infected herds located in the high risk area (n = 60), incremental spatial correlation analysis of the log-transformed βs revealed the occurrence of highly significant positive autocorrelation (p = 0.0003–0.036) between 6 and 14 km distance with a peak at 12 km ( Fig. 2 ).

Table 3 provides the ANCOVA p-value for composite scores, showing that the coefficient for treatment, adjusted for pre-treatment scores, is highly significant ( P = 0.0003).

Even applying a simple sign test [22] , if we assume each of the runs shown in Figure 4 is an independent test of the null hypothesis, the difference between conditions is highly significant (N = 13, p = 0.0003).

As would be predicted, a highly significant negative correlation was also observed between PARP activity and NAD + levels ( Fig. 6B , r = −0.638; p = 0.0003).

largha , all of these values being highly significant at P < 0.0003 according to Student’s t -test results.

The partial correlation between CORR_CVS and TARG_LET remained highly significant (R = 0.67, p = 0.0003).

However, the OR associated with INSTI use is highly significant [7.67 (2.54–23.2), p = 0.0003] and a larger population would have most probably affected the CI95% of the OR but not the direction of the association even if we cannot definitively rule-out the possibility of an allocation bias secondary to a small selected subgroup of patients receiving raltegravir.

Statistical analysis revealed that the effect observed in shMcl-1 cells was highly significant (P≤0.0003; Fig. 5C ).

Size metrics show highly significant differences: mean Feret diameter (U = 87, p = 0.0003, r = 0.64), median Feret diameter (U = 90, p = 0.0004, r = 0.62), and SD Feret diameter (U = 120, p = 0.0045, r = 0.50), with Los Villares exhibiting larger and more variable grain sizes.

These differences in both input resistance (P<0.002) and sag were highly significant (P<0.0003), and remained significant when the single recording with the highest input resistance in the control group (which might be considered an outlier) was discounted.

Overall the tetanic stimulation resulted in a highly significant alteration in the EPSP-IPSP patterns (p=0.0003; Rank-Sum-Test).

In the fuzzy seed trial, the analysis of germination and yield data displayed highly significant differences (P = 0.0003) among the light treatments (Figs 18 and 19 ).

Despite the fact that few within experiment comparisons resulted in significant effects of p CO 2 , patterns in carbon removal and bacterioplankton growth dynamics were consistent across all experiments and locations, and are highly significant: cell-specific TOC removal ( Fig 4 ) and bacterioplankton carbon demand ( Fig 5 ) were consistently enhanced at elevated p CO 2 (p-value = 0.0003, Fisher’s sign test; p-value < 0.0001, t-test, respectively), while bacterioplankton growth efficiency ( Fig 6 ) was significantly reduced at elevated p CO 2 (p-value = 0.0003, Fisher’s sign test).

The comparison of the spectral counts in the inflammatory/immune category was highly significant ( Z = −3.16, P -value = 0.0003), while the comparison for all other proteins was not significant ( Z = 0.3602, P -value = 0.7206).

Surprisingly, we noted a considerable reduction in calcification: Ca5 sHAoSMC exhibited a highly significant 60% reduction (24.1%, 95%CI 16.5–31.8%, p = 0.0003) in calcification compared to unstrained Ca5 cells.

We sought replication in independent samples for this marker and found highly significant association ( p = 0.0003) in 3 Caucasian replication samples.

The relationship between STX1A and PC1 remains highly significant (one-tailed Pearson correlation, n = 62, p = 0.0003).

There was a highly significant subretinal treatment effect on ERG amplitudes collectively at 7–9 months post-injection (p = 0.0003).

Importantly, we observed highly significant (p<0.0003) and positive (R 2 >0.62) correlations between levels of differentially expressed transcripts identified in the presence of ouabain and K + -free medium ( Fig. 4 ).

Finally, as expected, the explicit negative information for females (“Females are worse”) leads to a deterioration in performance of females and an enhancement in performance of males resulting in a highly significant gender effect (10.78±2.52 and 8.24±2.44, for males and females, respectively; t (49) = 3.89, p <0.0003; effect size, Cohen's d = 1.02).