Barely Significant

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Regarding Patient #1: how do you know that CHDF “consistently removed the metabolites such as creatinine, L-cartinine, TMAP and iohexol with time”(lines 207-208)? Were you using an internal standard? It is difficult to estimate a decreasing trend when the Y-axis units are expressed in %. 2.
Considering the evidence of a possible trend of slight decrease of the overall lung cancer incidence during the same period [ 20 ], the latter assumption might have led to an under-estimation of SE of the final version of the proposed NSCLC-finding algorithm from 2014 onward (in 2014 the SE max was 39% and min 35%).