Excerpts

In other words, organisms sampled from a defined skin habitat were more similar to each other in 16S sequence than expected for a global background; this enrichment was statistically highly significant (p<<10 −16 , one-sided Mann-Whitney-U test, see Table S1 ).

Although it displays limited power, the PRS predictor is highly significant ( P < 1.0 × 10 −16 ), and an analysis of variance (ANOVA) between the full PRS model against the null model using covariates only is significant ( P = 1.9 × 10 −12 ), confirming the additional classification accuracy conferred by the PRS predictor.

Twenty-four GST peptide isoforms were identified under seven different classes with a highly significant protein-protein interaction between GST groups and within other detoxification metabolism-related peptides ( p -value < 1.0 × 10 −16 ).

A highly significant proportion of these genes (Figure 4A and B and Supplementary file 5) (599, hypergeometric P < 1e−16) are also within 25 kb of 961 TP53 binding sites, potentially representing direct TP53-induced target genes (Figure 4B and C ), many of which, such as CDKN1A , are associated with multiple TP53 sites.

The correlation between RNA-seq fold changes computed on the data from day 2 versus that from day 4 was highly significant (r = 0.50, P<10 −16 , Figure S2A ).

The PPI network showed a highly significant enrichment with a p-value of <1.0e −16 and an average local clustering coefficient of 0.707.

The trend is weaker in lincRNAs compared with protein-coding genes (rho = 0.2 and 0.28, respectively) but both correlations are highly significant (from Spearman: P < 10 − 16 ).

Functional network analysis of BAs: insights from protein–protein interaction (PPI) analysis The PPI analysis conducted using the STRING database revealed a highly significant enrichment of interactions among the analyzed proteins (PPI enrichment p-value < 1.0e−16), indicating a biologically relevant network rather than a random association.

The expected number of edges is 393 and has a PPI enrichment p -value was highly significant ( p < 10 −16 ).

For the secretome of ET-eMSC, the enrichment of low and high abundance proteins was highly significant ( p < 10 −16 ).

The analysis revealed a highly significant interaction network among the differentially abundant proteins ( p < 1.0 -16 ), indicating that down-regulation of these protein interactions may play a crucial role in modulating intracellular biological processes in pigs fed a BET diet. 3.2.

These results show that all four topological measures provide highly significant ( p -value < 1e-16) enrichment in pathogen targets, with betweenness and clustering coefficient displaying highest enrichment, thereby demonstrating the added value of incorporating PPI data into inferred networks for a generalizable approach to identify target regulatory nodes within networks.

First, and as noted by other studies [ 19 , 20 ], we saw a highly significant difference ( P << 10 -16 ) in the AFS of silent versus missense variants (Figure 5a ) with a skew towards rare alleles in the latter, so that approximately 63% of missense variants were <1% in frequency whereas approximately 53% of silent variants fell into this category.

The 48 proteins consistently enriched in plaques in both EOAD and DS also showed a highly significant degree of protein–protein interaction ( p < 1.0 × 10 –16 ; Fig. 3 D) and were almost exclusively classified as either vesicle (enrichment FDR: 4.32 × 10 −9 ) or extracellular proteins (enrichment FDR: 3.34 × 10 −8 ).

As expected, our meta-analysis confirmed a highly significant association between the GTF2I rs117026326 polymorphism and pSS (OR = 2.17; 95% CI = 2.00–2.34, p < 1 × 10 −16 ) ( Figure 4 A).

41 All clocks demonstrated a strong and highly significant correlation with the biologic age, with the skin and blood clock demonstrating the strongest correlation (Pearson R = .96; 95% CI, 0.959–0.97; P <1 × 10 16 ) ( Figure 8 A ).

Initial mapping using an imputed genotype matrix for 2029 accessions (Togninalli et al ., 2018 ) revealed a highly significant peak associated with symptom score and total SA levels (−log 10 ( P ) = 15.96 and 10.64, respectively) spanning over 10 Kb on Chromosome 2 (Figs 1 , S2 for SA) and one marker reaching significance on Chromosome 3 (−log 10 ( P ) = 7.59) that is only associated with symptom score.

AgeAccelGrim remains a highly significant predictor of lifespan after restricting the analysis to never-smokers (N=3,988, meta analysis P=1.1E-16, Supplementary Fig. 9 ) or to former/current smokers (P=3.5E-33, Supplementary Fig. 3A ).

The M3 from the Japanese cohort wholly covered all the genes involved M11 from the TCGA cohort, which is highly significant overlap (n=41, hypergeometric test, P < 1.1e-16, Figure 2 g).

Irrespective of clades, all strains treated with 4 wt%Ag/TiZSM-5 zeolite and Ag-silicalite-1-nanomaterial showed highly significant inhibition for both biofilm [(24 h; F = 57.4079 and p = 1.1102 × 10 −16 ) (48 h; F = 43.3833 and p = 1.1 × 10 −16 ) and planktonic C. auris, compared to the control conditions.

It was found that the level of significance was highly significant ( P = 1.1102e-16).

The enrichment of SRCAP variants in the Caribbean Hispanic patients with LOAD was highly significant at p = 1.19e-16.

As shown in Table 1 , the pMHCs that induced higher contact areas also induced more rapid initial spreading, although the initial spreading rate displayed only 1.8-fold variation depending on stimulation peptide, but peptide discrimination remained highly significant ( p = 1.3 × 10 −16 ).

During the active period with lights off there was a highly significant difference between males and females (p = 1.3E-16) and also some difference between sites (p = 1.1E-3) with a significant interaction between site and sex (p = 3E-6) ( Fig 6a and 6b ).

This up-regulation was highly significant on meta-analysis (Fisher’s combined P = 1.4 × 10 −16 , Fig. 2C ).