Excerpts

The network showed highly significant PPI enrichment (p < 1.0 × 10 −16 ), with an average node degree of 3.52 and a local clustering coefficient of 0.497, supporting the presence of a non-random and moderately clustered interaction structure.

In sharp contrast, the STRING analysis found a highly significant connection enrichment in the MSI-H overexpressed proteins ( Fig. 3 B ; p -Value < 10 −16 ).

We did a survival analysis with the 82 commonly downregulated genes in lung cancer using KM plotter, and an extremely significant favorable outcome was associated with higher expression of the set of genes (H = 0.35, p < 1 × 10 −16 ) in lung cancer patients ( Figure 4 C).

By a STRING protein-protein interaction network analysis of proteins identified by MS, we determined a highly significant network of proteins being bound to the nimtRNA transcript ( p < 1.0e−16).

The network showed strong biological relevance with highly significant enrichment ( p -value < 1.0e-16).

The interaction network between identified proteins in the osteocyte secretome reveals a highly significant degree of protein‐protein interaction ( P < 10 ‐16 ) as illustrated in Figure S1 .

Each result is highly significant ( p < 10 −16 , for each predictor.

All were highly significant ( p < 10 –16 for all chromosomes after Bonferroni correction), with over 96% of the variation in the F5 position being explained by the F2 position for every chromosome tested ( Figure 2 ).

The expected number of edges is 393 and has a PPI enrichment p -value was highly significant ( p < 10 −16 ).

This enrichment in interactions was further supported by a highly significant PPI enrichment p -value of <1.0 × 10 −16 , indicating that the proteins in our network have more interactions among themselves.

Starting with the GO gene sets, we found a highly significant enrichment in genes related to the innate immune response particularly (p = 1.×10 −16 , FDR = 1.36 × 10 −12 ).

The enrichment was highly significant (PPI enrichment p < 1.0e− 16 ), demonstrating that the observed interactions were unlikely to occur by chance.

The fits showed a highly significant effect of light angle (p < 10 −16 ) on the perceived walking direction for both true walking directions (AWAY and TOWARDS).

We have applied a statistical test and found that all of the comparisons of short gene expression to longer gene expression are highly significant (p-values <10-16, Kolmogorov-Smirnov test).

STRING analysis revealed a highly significant enrichment of protein–protein interactions (PPI enrichment p < 1.0 × 10 −16 ), confirming that the identified proteins are functionally connected rather than randomly associated.

The resulting network comprised 78 nodes and 254 edges, exhibiting a highly significant PPI enrichment ( p < 1.0e-16, Figure 4 ).

Initial mapping using an imputed genotype matrix for 2029 accessions (Togninalli et al ., 2018 ) revealed a highly significant peak associated with symptom score and total SA levels (−log 10 ( P ) = 15.96 and 10.64, respectively) spanning over 10 Kb on Chromosome 2 (Figs 1 , S2 for SA) and one marker reaching significance on Chromosome 3 (−log 10 ( P ) = 7.59) that is only associated with symptom score.

AgeAccelGrim remains a highly significant predictor of lifespan after restricting the analysis to never-smokers (N=3,988, meta analysis P=1.1E-16, Supplementary Fig. 9 ) or to former/current smokers (P=3.5E-33, Supplementary Fig. 3A ).

The M3 from the Japanese cohort wholly covered all the genes involved M11 from the TCGA cohort, which is highly significant overlap (n=41, hypergeometric test, P < 1.1e-16, Figure 2 g).

Irrespective of clades, all strains treated with 4 wt%Ag/TiZSM-5 zeolite and Ag-silicalite-1-nanomaterial showed highly significant inhibition for both biofilm [(24 h; F = 57.4079 and p = 1.1102 × 10 −16 ) (48 h; F = 43.3833 and p = 1.1 × 10 −16 ) and planktonic C. auris, compared to the control conditions.

It was found that the level of significance was highly significant ( P = 1.1102e-16).

The enrichment of SRCAP variants in the Caribbean Hispanic patients with LOAD was highly significant at p = 1.19e-16.

During the active period with lights off there was a highly significant difference between males and females (p = 1.3E-16) and also some difference between sites (p = 1.1E-3) with a significant interaction between site and sex (p = 3E-6) ( Fig 6a and 6b ).

As shown in Table 1 , the pMHCs that induced higher contact areas also induced more rapid initial spreading, although the initial spreading rate displayed only 1.8-fold variation depending on stimulation peptide, but peptide discrimination remained highly significant ( p = 1.3 × 10 −16 ).

This up-regulation was highly significant on meta-analysis (Fisher’s combined P = 1.4 × 10 −16 , Fig. 2C ).