Excerpts

Highly significant increases in median nFLAIR, CNI, and CCrI were observed for NAV→NEL ( p = 1.5 × 10 –16 , 2.4 × 10 –15 , 2.8 × 10 –16 , respectively) voxels compared to stable NAV voxels, while increases in median nADC also reached a statistical significance of p = 0.0009.

In the univariate model, PIP (chosen to represent all other heart rate fragmentation measures) demonstrated a highly significant ability to predict mortality (p = 1.71E-16).

The molecular essence of all samples was consistent between measurements on the solariX and scimaX systems, with ANOVA revealing highly significant differences among sample groups ( p < 2 × 10 –16 ).

The two factors were therefore stimulus contrast (0–64%), which produced a highly significant effect, F (6, 1287) = 171.83, p < 2 × 10 −16 , equivalent d = 1.78, and mask contrast (0 and 32%) which produced a smaller effect, F (1, 1287) = 12.89, p < .0004, equivalent d = 0.19.

Of these 316 genes, 81.5% (256) were found in our original list, a highly significant overlap ( P < 2 × 10 -16 , Fisher's exact test), demonstrating the reproducibility of our methodology.

Distance to the sea is also highly significant (R 2 = 0.47, p <2e -16 for Tajima’s D).

3 ), with a highly significant genotype effect ( p -value < 2 × 10 −16 ).

As expected, the PY effect was highly significant (P < 2 × 10 −16 ), and the smoking group W5Y remained significant after correcting for PY (P = 0.008).

An analysis using Pearson's correlation coefficient indicates a highly significant linear relationship between bioactivities measured against human and rat targets (r = 0.71, p<2e-16).

To statistically confirm the effectiveness of this discrimination, we also conducted an ANOVA test, which showed a highly significant separation among the groups (F 2, 117 = 355.6, p < 2e –16 ).

Vials of APSA stored on ice in the fridge for up to 22 months and then sampled at a dilution factor of 1/250,000 (DF 250,000) prior to assay showed extreme sample to sample variation in enzyme activity and a trend to lower OD values over time with a highly significant effect of the storage time on the detection limit (ANOVA p ≤ 2E-16, Regression p < 0.043) ( Fig. 2 A).

Specifically, comparisons between the ≥5-year group and both the 3–4-year and 0–2-year groups were highly significant (both p < 2 × 10 −16 ), as was the comparison between the 3–4-year and 0–2-year groups ( p = 0.0037).

Smooth terms for latitude and longitude were highly significant (p < 2 × 10−16), further confirming the spatial structure of life expectancy outcomes.

Using the aggregated network, we observed that the number of first-degree protein partners was higher in selected MR gene-traits as compared with gene-traits that did not reach statistical significance ( p < 2e−16).

The difference in this distribution was highly significant ( χ 2 p-value<2e-16).

We found the effect of rurality to be highly significant ( P < 2.0 × 10 -16 ), but it explains only 28% of the overall variation in log positional error magnitude.

Laminar quantification showed a highly significant difference in Iba1 intensity across cortical layers [ F (4,531) = 90.19, p < 2 × 10 –16 ; one-way ANOVA] with the highest intensity in L1 ( Figure 7E ; L1 vs.

The enrichment of TEs at species-specific binding sites were highly significant both with a chi-square test (Hs χ 2 = 142.8, Mm χ 2 = 131.4, both p < 2e −16 ) and with permutation tests (n = 10,000, p < 1e −5 ) ( Fig 5A ).

Finally, LASSO analysis was not adjusted for age due to its high correlation with diagnosis (Pearson r = 0.74) and strong potential for solely predicting diagnosis, indicating a highly significant association (logistic regression estimate = 0.225, p < 2e‐16, Akaike information criterion [AIC] = 124,231).

This was found to be a highly significant over-representation by goseq (Bonferroni adjusted p -value < 2 × 10 –16 , see Figure 2A and Supplementary Data File 2 ).

The intersection is statistically highly significant (p < 2 -16 ).

Again, rs708727 was found to be a highly significant ( p < 2e−16) covariant of all probes, while rs960603 is not.

The effect of time alone was highly significant (P< 2 × 10 -16 , 99.999% CI), though genotype-time interaction was not statistically significant (P = 0.4904, 5% CI) ( Figure 5C ).

Thus, although the number of substitutions in a partition is a highly significant ( P < 2e-16) predictor of passing or failing any of the tests, that it explains only about a quarter of the variation suggests that other factors, such as underlying differences in the extent to which partitions violate the SRH assumptions, are driving the remaining ∼75% of the variation.

We found that both RM and n sites had a highly significant effect (respectively, F 9,449 = 71, P < 2 × 10 −16 and F 1,449 = 103, P < 2 × 10 −16 ), and the interaction between RM and n sites was also significant ( F 9,449 = 8.99, P < 2 × 10 −16 ).