Excerpts

All coefficients were statistically highly significant (p<0.001).

The difference of probe detection between probes with short SOA and probes following no onset distractor was highly significant ( t [21] = 6.21, p < 0.001, Cohen's d = 1.32, 95% CI [0.65, 1.99]).

Clinical Global Impression (CGI) A highly significant treatment effect was found on the CGI scale, with a benefit of − 0.63 (− 0.84; − 0.47; p < 0.001, Suppl. 9.2.1) compared with the placebo, confirmed by the results from the SMM model − 0.67 (− 0.97; − 0.36, p < 0.001, Suppl. 9.3, Fig. 1 ), and found to be homogeneous among studies.

The sensitivity of CHIKV E2 envelope protein was higher than that of CHIKV E1 envelope protein, even though there was a highly significant correlation in the seroreactivity between CHIKV E1 and E2 envelope protein for anti-CHIKV positive serum samples ( p < 0.001).

Highly significant ( p <0.001) forward stepwise multivariate regression models of ecosystem observations demonstrated that D . acuminata abundances were positively dependent on multiple environmental parameters including ammonium ( p = 0.007) while cellular toxin content was positively dependent on ammonium ( p = 0.002) but negatively dependent on nitrate ( p <0.001).

A comparison of participants with severe chronic tinnitus and controls revealed a significant trend toward bilaterally reduced benzodiazepine receptor density in the frontal lobes ( p < 0.001) and a reduction in the cerebellum ( p = 0.045) ( Daftary et al., 2004 ).

There was a significant trend (p < 0.001) of increasing non-participation with increasing categories of obesity in sensitivity analysis excluding underweight women.

Accordingly, age distribution differences were highly significant ( p < 0.001), with isotretinoin over-represented in adolescents and topical retinoids more frequent in children and older adults, potentially reflecting off-label or non-acne use of topical agents.

Similarly, a highly significant reduction in SBP ( p < 0.001) and MBP was observed at third hour.

We observed an increasing trend in incidence with age, from 0.3% among those 40 to 49 years, and up to 2.1% among those 70 years or older( P < 0.001).

There were strong highly significant correlations between calf muscle fat fraction and CMTES (Spearman ρ = 0.798, P < 0.001) and between calf muscle fat fraction and the lower limb motor components of the CMTES (Spearman ρ = 0.813, P < 0.001).

Similarly, MMSE scores declined across the diagnostic spectrum, with all between-group comparisons remaining highly significant ( p < 0.001).

In the sensitivity analysis, even in patients without very severe AS defined by V max or MPG criteria, the excess risk of group 3 relative to group 1 was highly significant (HR, 1.81, 95% CI, 1.21–2.71; P <0.001), whereas the excess risk of group 2 relative to group 1 was no longer significant (HR, 1.27, 95% CI, 0.95–1.70; P =0.11).

For the genus data set, when comparing each pair of samples, clustering was highly significant (raw p<0.001 and after the Bonferroni correction for multiple comparisons, p<0.002).

We found a highly significant increase in acceptability for “many” [ t (20) = −7.79; p < 0.001], and a decrease for “few” [ t (20) = 2.58; p = 0.018] (one-tailed t -tests, p -Bonferroni-corrected).

As expected, there was a highly significant inverse moderate correlation between repeat length and disease severity for both the Ricci age-corrected Clinical Score (ACCS) (R = −0.491, p < 0.001) and the age-corrected FSHD Clinical Score (R = −0.532, p < 0.001) (Fig. 4 ).

Our study revealed a significant trend (p=0.001) of lower survival rates (18%) for patients in very remote areas compared with rural (46%) or regional (52%) areas.

Vegan subjects therefore disclose highly significant ( p < 0.001) downsizing of their LBM and SM values [ 84 ].

However, there was a highly significant difference between outcome groups ( F = 129.383, p < 0.001).

Highly significant positive correlations were found between EE and both EOE ( r = 0.35, p = 0.001) and LST ( r = 0.30, p = 0.003).

Very highly significant ( P < 0.001) reductions in N-terminal pro-brain natriuretic peptide (NTproBNP) were documented in the patients randomized to levosimendan; these were accompanied by profound reductions in the risk of HF-related hospitalization (12-month cumulative hospitalization rate ≈20% vs. ≈65% in the placebo group; P < 0.001) and in the composite endpoint of all-cause mortality or HF-related hospitalization (12-month cumulative hospitalization rate ≈25% vs. ≈65% in the placebo group; P < 0.001).

We found an increasing trend in the number of surgeries for Brazil (β=0.04; p<0.001), but 11 FUs showed a stationary trend and three, decreasing ones (six UFs did not have enough data to enter the analysis).

There was a decrease in mean post procedural platelet count (27.5%), white blood cell (WBC) count (4.02%), mean serum calcium (1.5%), and serum magnesium (5.1%), which was statistically highly significant ( P < 0.001).

Gallbladder wall thickness showed minimal variation between groups and remained within normal limits Gallbladder stones were significantly more prevalent in SCA patients (20.0%) compared to controls (7.5%), with a highly significant chi-square result ( p < 0.001).

However, on the basis of the MRS total score and the individual domains, highly significant results with regard to the total score ( p < 0.001) and significant results with regard to the somatovegetative and urogenital domains ( p < 0.05) remained (Table 8 ).