Excerpts

There was a notable trend toward lengthening of the 3’UTR in cancer cells ( P = 5.59 × 10 −20 ), with COL1A2 emerging once more as the most prominent finding ( P corr =7.48 × 10 −47 , 61% change) (Figs. 3b, c and 4f ).

Comparison of the WP and ACRG subclusters revealed that 67.39% (31/46) of MSS/EMT patients corresponded to the EMT cluster, whereas 73.42% (58/79) of MSS/TP53+ patients associated with the metabolism cluster, contributing to a highly significant statistical correlation between WP subclassification and ACRG subtyping ( P = 4.6 × 10 −19 ) (Tables S4 and S5 , Fig. 3A,B ).

Language Related to Self-experience Could Infer Clinical Symptoms CCA conducted in the training sample revealed a highly significant relationship between language features and the PANSS ( r = .62, P < 10 −18 ; figure 3A ), and those linear combinations of the PANSS subscales and language factors were validated in the testing set ( r = .59, P < 10 −6 ; 3B).

There are higher D2:B6 ratios in the CpG high sequence density regions than in the low, and because there are so many more sites without mutations, the effect is highly significant (p = 4.11e−18), but the increase is much smaller than that found in regions with mutations (mean ratio in high: 0.034, mean ratio in low: −0.001).

The distribution of iHS scores for the entirety of the chromosome 12 iHS values (minus the LRRK2 locus) was bootstrapped and suggested that this cluster was highly significant compared to scores for the rest of the chromosome ( p = 4.50 × 10 −18 ).

Analysis of the gene expression levels in multiple breast cancer cell lines ( Figure 3A , Figure 3—figure supplement 1A ) revealed weak but statistically highly significant correlations between the levels of MEMO1 and TFR1 (p = 4.6E-18), TFR2 (p = 1.8E-14), and PLOD1 (p = 1.8E-33).

The difference between these two slopes was highly significant ( t (72) = −11.5; p = 6.1×10 −18 ).

Whereas, RNA M of newly reported Chinese isolate YNKM-2 had one highly significant recombination event ( P -value = 6.586 × 10 − 18 ) spanning from 3111 to 3811 bp (without gaps), detected by seven algorithms i.e., RDP, GeneConv, Bootscan, MaxChi, CHIMAERA, SisScan, and 3SEQ.

Using this approach, we found that the positive association between CAI and logPPR was highly significant ( G = 72.977, df = 1, P = 1.31e-17).

The changes in AUC-ROC were not statistically significant (DeLong p -values of 0.922, 0.902, and 0.750 respectively); however, the McNemar test was highly significant ( p = 1.39 × 10 −17 , 5.23 × 10 −30 , 2.25 × 10 −24 ).

The effect of the stimulation level was highly significant (two-way ANOVA, F 2, 54 = 84.53, p = 2.3 × 10 −17 ).

This was again underpinned by the ANOVA analysis, reporting a highly significant influence of the flyer ( p < 10 − 16 ), but only a weak influence of the base ( p ≈ 0.086 ).

The resulting network comprised 78 nodes and 254 edges, exhibiting a highly significant PPI enrichment ( p < 1.0e-16, Figure 4 ).

In each of the hippocampus, amygdala, thalamus, caudate, nucleus accumbens, and brainstem, one or more diffusion metrics were highly significant with P < 10 −16 .

Accordingly, the removal of these functional factors leads to a highly significant association between GC content and recent positive selection (slope = 0.49; P < 1E−16; supplementary Results S3: table S4, Supplementary Material online).

The difference between the two distributions was highly significant ( p < 10 −16 , two-sided Wilcoxon rank-sum test).

DAPs Are Involved in Wound Repair and Blood Coagulation Are Associated with Hydration Protein–protein interaction analyses of DAPs using STRING [ 19 ] resulted in a highly significant clustering (PPI enrichment value of p < 1.0 × 10 −16 ) consisting of 34 nodes and 126 edges ( Figure 2 ).

Starting with the GO gene sets, we found a highly significant enrichment in genes related to the innate immune response particularly (p = 1.×10 −16 , FDR = 1.36 × 10 −12 ).

The PPI network comprised 51 nodes and 283 edges, with a highly significant enrichment (PPI enrichment p-value < 1.0e-16) as shown in Figure 4A .

This evidence of highly significant PPIs (actual edges = 1015, expected edges = 405, P < 1.0 × 10 −16 ) and highly ASD-relevant GO BP enrichment showcases a clear example of how the PFC sex*genotype DE genes are embedded within a complex systems-level biological pathology that integrates abnormalities along these key processes and pathways.

Acquisition and analysis of intersection targets of ROSA and CHIKV- The PPI analysis of the CHIKV disease target network revealed a total of 502 nodes and 1,386 edges, with a highly significant p-value of < 1.0e-16 ( Figure 2A ).

Each result is highly significant ( p < 10 −16 , for each predictor.

There is a highly significant correlation between F ST and A ancestry difference between the lowland and highland samples (Spearman's ρ = 0.26, P < 10 −16 ).

The protein–protein interaction enrichment was highly significant ( p -values < 1.0 × 10 –16 ) for both #BiAll-93 and #MonoAll-2.13 (Supplementary Table 4a, b), and most of the proteins grouping together were linked to six distinct biological functions (Fig. 3 d–f). #BiAll-93 and #MonoAll-2.13 cells shared a cluster, representing the combination of four Gene Ontology (GO) terms that were associated to stress response, cell adhesion and proliferation, and processes of cellular and organismal development.

The PPI network showed a highly significant enrichment with a p-value of <1.0e −16 and an average local clustering coefficient of 0.707.