Excerpts

Besides mean values, the paired t tests of the IASs were highly significant between IASs from different SDs ( p < 2.2 × 10 − 16 ).

239.3 cm) compared to Sb, and in both cases differences resulted highly significant ( p = 2.2×10 −16 and p = 2.7×10 −15 for MAT and PH, respectively).

Of the 236 transposable elements detected in our RNA-seq data, 97 are differentially expressed in xct-2 , representing a highly significant enrichment (1-tailed Fisher's exact test, P < 2.2e–16; Fig.

The reversal DEGs obtained from the dataset for each cell type were highly significant, based on empirical null distribution (B cells: n=24, p-value <2.2×10 −16 ; CD4+ T cells: n=67, p-value <2.2×10 −16 ; CD8+ T cells: n=108, p-value <2.2×10 −16 ; monocytes: n=183, p-value <2.2×10 −16 ; NK cells: n=66, p-value <2.2×10 −16 ) ( supplementary figure S5a–e ).

This reduction was highly significant with a p -value < 2.2 × 10 −16 ( Figure 2 ).

The concordance in pathway deregulation was maintained at the gene level, as we observed a highly significant correlation ( P value < 2.2 × 10 −16 ) between the global change in gene expression in the two mutants compared to the WT ( Fig. 3b ).

We found highly significant strong positive correlation between the RNA-seq and qRT-PCR data (Pearson’s r=0.954, p <2.2e-16) (Figure 5 ).

The observed overlap was highly significant ( P value < 2.2 × 10 −16 ), indicating strong concordance between the 2 datasets.

Strikingly, PFC Aliceblue and NAc Cadetblue 2 showed a highly significant overlap in their gene content, with 72 overlapping genes ( S2 Table ; p = 2.2 x 10 −16 ).

The correlation between predicted and measured scores was highly significant ( Figure 3C , Pearson’s r = 0.35, p < 2.2×10 −16 ) and reduced substantially when a randomized version of the ontology was used ( r = 0.04); the maximum achievable correlation, as previously determined by experimental genetic interaction replicates ( Baryshnikova et al., 2010 ), was r = 0.67.

We find a highly significant correlation (ρ = 0.15, P < 2.2 × 10 −16 ) ( Supplemental Fig.

Regression analyses indicate a highly significant relationship between PSC accuracy ( cf . empirical species richness) versus wia ( F 1,8190 = 5615, adjusted R 2 = 0.4067, p < 2.2e−16; Figure 4a ), whilst the relationship weakens when positive (WIA) and uninfected (uWIA) predictions are combined ( F 1,8190 = 1933, adjusted R 2 = 0.1909, p < 2.2e−16; Figure 4b ).

Results Phenotypic variance decomposition and heritability of partial resistance to bacterial canker Considering differences between all controls and inoculated shoots regardless of the genotype effect, a highly significant effect of bacterial inoculation was observed (Wilcoxon unilateral t.test p < 2.2E-16) for lgc whatever the year and for bs in 2013 and 2015 (lesser extent in 2014 p < 9.77E-12 and 2016 p < 9.06E-06).

FT showed a highly significant difference between groups (p < 2.2 × 10 −16 ), with substantially higher survival observed in Eastern European genotypes compared to those from Southern Europe.

The difference between significantly down-regulated genes on 22q11.2 compared with the number of significantly differentially expressed genes on the rest of chromosome 22 was highly significant (χ2 test p -value < 2.2e-16).

Multivariate linear regression analysis detected a highly significant association between blood-based DNAm-age acceleration and ALS age of onset (adjusted p value = 2.2E-16, B = − 1.29, R 2 = 0.33, n = 249) (Supplementary methods, Fig. 1 a), suggesting that for every 5-year increase in DNAm-age acceleration there is a 6.4-year earlier onset.

Fisher’s exact test revealed a highly significant association between treatments and inhibition scores at both 24 hpi and 96 hpi ( p < 2.2 × 10 −16 ).

Moreover, the relationship between the two methods of load estimation was highly significant (F 1,72 = 2420, p = 2.2 × 10 −16 ), and the slope was not significantly different from 1 (0.96, 95% CI [0.97, 1.05]), supporting the hypothesis that only Wolbachia w Sc1 and w Sc2 circulate in the S. cleopatrae flea populations.

We observed a highly significant effect of humidity (GLMM: p < 2.2e−16, x 2 = 266.93, df = 4; Table 2 B; Fig. 3 ) on T p of adult flies.

Results Descriptive statistics Samples differed in average symptom endorsement: Patients in Data Set 4 had the most severe symptomatology, followed by Data Set 1, Data Set 2, and Data Set 3 (see Table 1 ). Except for the comparison of Data Set 1 with Data Set 2, t (840.15) = 1.62, p = .11, Bayes factor = 0.26, 3 all other differences between the severity scores were highly significant ( t values between 8.51 and 29.29, degrees of freedom between 518.03 and 1417.3, all p values < 2.2 × 10 −16 , all Bayes factors > 4.7 × 10 13 ).

The median Laa value for SCT strain-specific genes (183 aa) was smaller than that for the other genes (280 aa), the difference being highly significant according to a Wilcoxon rank sum test ( p -value < 2.2e-16).

The Pearson correlation coefficients of uniquely mapped reads between biological replicates are from 0.961 to 0.994, which are highly significant ( p -values < 2.2e−16).

Based on the comparison of intact to degraded cartilage, the log-fold-changes in RNA expression and the differences in mean promoter region methylation values demonstrated a small but highly significant correlation (Pearson’s r = −0.08, p < 2.2 × 10 −16 , Fig. 2b , Supplementary Table S7 ).

The mean values of the non-invasively measured community-wide parameters obtained by DWCP seem to give a valid representation of the actual plant community as indicated by the highly significant positive relationship between the weighted plant biomass removed from sods and the digital biomass extracted from scans (quadratic polynomial regression, p < 2.2e-16, adjusted R 2 = 0.59, see Additional Figure 3 ), supporting results from scans of plant individuals ( Laxman et al., 2018 ).

In addition, the correlation between gene expression and TF binding was highly significant ( P = 2.2× 10 −16 , see Additional file 1 Supplementary Methods) and the likelihood of a TF complex near transcriptionally active genes showed that the TF complexes are most likely located -1kbp to 0.5kbp around TSS (Fig.