Excerpts

This correlation was highly significant ( p < 2.2 × 10 −16 ), indicating that the observed similarity is unlikely to occur by chance. 2.4 Expression of PAMPs and DAMPs in Human and Murine pDCs Quantitative proteomic comparison of human and murine plasmacytoid dendritic cells (pDCs) revealed selective, pathway‐specific differences rather than global proteome shifts.

Of these orthologs, 5,292 genes were located on the autosomes and 942 on the X chromosome, resulting in a highly significant difference in their chromosomal distribution (chi-squared test, p < 2.2 × 10−16).

This difference was highly significant ( P < 2.2 × 10 −16 ).

We observed a very weak but highly significant correlation in synonymous heterozygosity between species (Pearson’s r = 0.14, p<2.2e-16), consistent with some degree of conservation for genic parameters of mutation rates and/or selection at Drosophila synonymous sites [ 58 , 70 – 74 ].

Results Descriptive statistics Samples differed in average symptom endorsement: Patients in Data Set 4 had the most severe symptomatology, followed by Data Set 1, Data Set 2, and Data Set 3 (see Table 1 ). Except for the comparison of Data Set 1 with Data Set 2, t (840.15) = 1.62, p = .11, Bayes factor = 0.26, 3 all other differences between the severity scores were highly significant ( t values between 8.51 and 29.29, degrees of freedom between 518.03 and 1417.3, all p values < 2.2 × 10 −16 , all Bayes factors > 4.7 × 10 13 ).

The Spearman’s rank correlation coefficient of 0.74 between all d(fl, endo, g) and d(com, endo, g) scores is highly significant ( P = 2.2e −16 ), reflecting resemblance in genome size and signal peptide content of free-living bacteria and commensals.

This revealed a highly significant agreement of the number of events between paired replicates (Supplementary Fig. 2b , Pearson's correlation 0.997, n = 30, two-sided, p value < 2.2e−16), indicating that uvCLAP events capture the amount of pulled down RNA exceptionally well.

The overall model was highly significant (likelihood ratio test = 256.5, p < 2.2 × 10−16).

As with sequence similarity, whereas there is a significant trend for proteins that are among the top 0.5% of co-expressing pairs to share related ligands, (χ 2 = 1.3e3, p < 2.2e-16), pragmatically the effect size is marginal and only 9.3% of the top 15% of co-expressed pairs show any SEA interactions at all ( Fig 1B ).

These tests were all found to be statistically highly significant, with p < 2.2 × 10 −16 .

R ESULTS Analysis of flexural strength values for all the study groups by two-way ANOVA indicated a very highly significant difference between the means of all main groups ( F = 14056.27, P < 2.2E-16) and between the means of subgroups ( F = 94.41, P < 2.2E-16) [ Table 1 ].

We find a highly significant linear relationship between ψ and Fop ( F = 5325, P < 2.2 × 10 −16 ) as well as a strong positive correlation, measured as Spearman’s rank correlation coefficient (0.825).

Based on the comparison of intact to degraded cartilage, the log-fold-changes in RNA expression and the differences in mean promoter region methylation values demonstrated a small but highly significant correlation (Pearson’s r = −0.08, p < 2.2 × 10 −16 , Fig. 2b , Supplementary Table S7 ).

The fitted model yielded LOD scores of 55.8, 41.1, and 45.7, and PVE values of 77.0%, 66.1%, and 69.9% in 2021, 2022, and 2023, respectively, with all effects being highly significant ( P < 2.2 × 10−16) (Table S5 ).

Before this correction, this correlation was strong and highly significant for the 800 μM HFF-TerT sample (Figure 6B , Spearman's ρ = 0.29, P < 2.2 × 10 −16 , asymptotic t test).

The degree of compartmental conservation is highly significant ( P < 2.2e-16), as ~80% of the genome shows consistent compartmental labeling in at least 16 samples and ~40% is invariant in all 21 samples, in contrast to 7% and 0% to be expected by chance, respectively (Supplementary information, Fig.

The correlation coefficients were relatively low (0.325, 0.323, 0.321, 0.312 and 0.250 at the PARTE temperatures of 23, 30, 37, 55 and 75°C, respectively) but highly significant (all P -values < 2.2e-16).

This difference in size between the three types was highly significant for both length ( F = 328.7, df = 368, p = 2.2e‐16) and weight ( F = 478.2, df = 368, p = 2.0e‐16), with highly significant differentiation between even the closest two types (kokanee and hybrid; length: F = 20.3, df = 301, p = 9.51e‐0; weight: F = 44.61 df = 301 p = 1.16e‐10).

Analysis of application inflow Davies‘ test for significance of breakpoints resulted in a highly significant change in the slope of the participant inflow ( p -value < 2.2e − 16 ).

Additionally, the P-value for accuracy being greater than the No Information Rate (NIR) was highly significant (P < 2.2e-16), indicating that the model’s performance was far superior to random chance.

The model revealed highly significant main effects of total body length (log 10 TBL) ( F = 3335.41, p < 2.2e‐16), indicating that mandible length strongly and predictably scales with overall body size.

The concordance score based on the χ 2 -test is highly significant (p < 2.2e-16), and the overall accuracy to clinical types is 71.6%, as measured by rand measure, a metric for the percentage of agreement on a pair of samples belonging to the same group.

All reported correlations were highly significant ( p < 2.2 × 10 −16 ).

For each month, the differences between soil and soil + root for COS and CO 2 were highly significant (Kruskal-Wallis rank sum test – p < 2.2e −16 ), with higher CO 2 and lower COS emissions in the soil + root chambers (except for February) (Fig. 3 ).

Zymo) (Additional file 1 : Figure S1A), with a highly significant correlation observed in both the prefrontal cortex (Additional file 1 : Figure S1B; R 2 = 0.99, P <2.2E-16) and cerebellum samples (Additional file 1 : Figure S1C; R 2 = 0.99, P < 2.2E-16).