Excerpts

Clustering of MBM regarding β-values of each CpG area revealed a highly significant ( p < 2.2e−16) separation of BRAF mut and BRAF wt /NRAS mut tumors (Fig. 8a , right panel).

The difference in the comparison of In100-element flanking exons and the control exon pairs is highly significant (Fisher's Exact Test, P<2.2×10 −16 , df = 1; Figure 4 ).

The Spearman’s correlation coefficients (ρ) between the positions of the markers on linkage map and physical map were positive (0.996-to-0.999) and highly significant (p-value < 2.2e -16 ), with an average of 0.999 ( Supplementary Table 5 ).

A Wilcoxon rank sum test indicated a highly significant difference in fitness variation ( W = 3.2 × 10 8 and P < 2.2 × 10 −16 ), supported by Welch’s t test, which showed a lower mean absolute fitness difference for closely related homologs compared to distantly related homologs ( t = −63.5, df = 7,020, and P < 2.2 × 10 −16 ; table S9).

Given that we observe 117 mutations in hypomethylated CGIs, but only expect 50.0 (117*(1/2.34*)) with the genome-wide autosomal mutation rate, this represents a highly significant enrichment (Poisson test, p = 2.2 × 10 −16 ).

As a result, we found a highly significant positive relationship between visual bleaching scores on Day 0 and Day 7 post-stress ( Fig 3A and S2 Table , linear mixed effects model, p < 2.2e -16 , marginal R 2 = 0.863, df = 44), such that VBS at Day 0 post-stress was highly predictive of VBS throughout the following seven-day period.

Since this group represents 13% of the upstream regions in the genome, this is a highly significant enrichment ( Fig. 6c , Fisher's exact test, P < 2.2 × 10 −16 ).

2 A), which was still highly significant ( p = 2.2e-16) due to the number of data points.

Regression analyses indicate a highly significant relationship between PSC accuracy ( cf . empirical species richness) versus wia ( F 1,8190 = 5615, adjusted R 2 = 0.4067, p < 2.2e−16; Figure 4a ), whilst the relationship weakens when positive (WIA) and uninfected (uWIA) predictions are combined ( F 1,8190 = 1933, adjusted R 2 = 0.1909, p < 2.2e−16; Figure 4b ).

Transcripts that lose m6A during differentiation show highly significant increase in TE in glioblastoma samples irrespective of subtype (GSC1: p<2.2e-16, GSC2: p<3.4e-11, GSC3: p<2.2e-16) (Fig B in S1 Text ).

This comparison resulted in 196 common antigens out of 481, a highly significant overlap (odds ratio: 6.4088; 95% CI: 5.3011–7.7479; chi 2 p -value < 2.2 × 10 −16 ).

We observed a highly significant difference in the mean correlation values ( P -value < 2.2e-16, lower-tailed Wilcoxon rank sum test), with a median correlation value of -0.15 for the differentially methylated promoters detected by MethylDriver, more than twice as strong as the average association for all promoters ( Supplementary Figure S4 ).

Analysis of variance based on the reparametrized polynomial-interaction model with MPR effects showed a highly significant impact of partial yields on test-day yields ( P <2.2e-16).

Our results demonstrate that subtype indicators are highly significant in predicting survival ( p -value < 2.2 × 10 −16 ).

Withdrawal of glutamine reduced global translation in both conditions, but there was a highly significant increase in translation driven by MYC compared to that seen in cells transduced with the pM6P vector in the absence of glutamine ( P value = 2.2 × 10 −16 ).

The difference in the location of the median for the success statistic distributions obtained using the two approaches was highly significant ( p < 2.2e‐16) for all three drugs and showed that the PopPK approach performed significantly better than a standard NCA approach.

IAPs are specific targets of Dnmt1’s de novo activity Next, we compared the DMR distribution over genomic features and found a highly significant enrichment at LTRs, which is independent of regional CpG density ( P < 2.2 × 10 −16 , Wilcoxon test, DMRs compared with CRs; Fig. 2e and Extended Data Fig. 2b ).

Interplatform adjustment led to a highly significant increase in ICC coefficients (median (prior to interplatform adj., only intraplatform adj.) = 0.1; median (after interplatform adj.) = 0.46; P < 2.2 e − 16).

Statistical analysis using an independent two-sample t -test (Welch’s correction) revealed a highly significant difference in mean PC1 values between the two groups ( P < 2.2 × 10 −16 ).

The 138 c-Jun-regulated genes showed a highly significant 5.8-fold enrichment (p=2.2×10 −16 ) among the 1581 genes regulated during chronic denervation.

Besides mean values, the paired t tests of the IASs were highly significant between IASs from different SDs ( p < 2.2 × 10 − 16 ).

0.00276, Fisher's exact test p-value = 1.34e-05), there is a highly significant excess of sites supporting the species topology (0.00229 vs. 0.00210, Fisher's exact test p-value < 2.2e-16) and deficit of sites in these regions supporting ILS topologies (0.00042 vs. 0.00066, Fisher's exact test p-value < 2.2e-16, Fig 2B and 2C ), which suggests that the observed reduction of ILS is not the result of a lower mutation rate.

The polarity score analysis of all expressed ORFs revealed a small but highly significant shift of ribosomes toward the 5′ end of ORFs when RPLP1/2 were depleted (mean of the differences = 0.013, P = 2.2 × 10 −16 ) ( Supplementary Figure S12A ).

We observed a highly significant gain of methylation with age at the locus in the LBC cohort, validating our approach (Fig. 1 a, T-test, p < 2.2 × 10 −16 ).

High phenotypic correlations were observed for both females ( r = 0.98) and males ( r = 0.95), with highly significant p values ( p < 2.2 × 10 −16 ).