Excerpts

There was a highly significant effect of orchard on epiphyte species richness per tree ( F 4,607 = 358.17, p < 2.2 × 10 −16 ) and a highly significant effect of cultivar nested within orchard ( F 5,607 = 20.92, p < 2.2 × 10 −16 ; Appendix S2).

This difference is highly significant ( P = 2.21 × 10 −16 ), considering that the mean ARE score for human mRNA transcriptome is 3.8 ( Spasic et al. 2012 ).

RNA-seq showed highly significant overlap in gene expression between acute degradation of RAD21-TEV and genetic cohesin depletion in Rad21 lox/lox Nex Cre neurons (p<2.22e-16, odds ratio = 8.24 for all deregulated genes, odds ratio = 23.81 for downregulated genes; Figure 4a ).

The samples were divided into two groups (normal group and tumor group) in TCGA-LUSC, and t -test on risk score of two groups showed quite significant in two groups (P<2.22e−16) (see Figure 6A ).

Pagel’s λ test indicated a very strong and highly significant phylogenetic signal (λ=0.99, P <2.22e-16), indicating that attC abundance is strongly structured by evolutionary history.

The spatial autoregressive parameter had a positive value and was highly significant ( p < 2.22 × 10 −16 ), indicating that endemism in a given area tends to increase with increasing endemism in surrounding grid cells (independent of the other parameters in the model).

For log propodus height, there was no significant difference in the angle of slope between males and females (p = 0.078), but there was a highly significant difference in slope elevation when slope angles were assumed to be equal (p < 2.22 x 10 −16 ) ( Table 2 ), with males having broader log propodus heights than females throughout the size distribution of log carapace lengths ( Fig 5 ).

Knocking out miR-983 caused a highly significant decrease in sperm length in D. melanogaster ( D. mel KO vs., D. mel WT: 1.724 ± 0.065 mm vs., 1.825 ± 0.047 mm; Wilcoxon rank-sum test, P < 2.22 × 10 −16 ; fig. 5 A ).

In this study, highly significant Pearson’s correlations ( p -value = 2.22 × 10 −16 ) among the mRNA expression of these genes were obtained (r ELOVL5-ELOVL6 = 0.90; r ELOVL5-SCD = 0.84; r ELOVL6-SCD = 0.86), supporting the involvement of common elements regulating their mRNA expression.

There was a highly significant correlation between mRNA stability and translation levels across all genes (Spearman’s rho 0.2; p<2.22*10 −16 ) ( Figure 2F ).

Notably, the NecropImmScore strongly correlated with immunophenotype score (IPS), with high-score tumors exhibiting significantly higher IPS across all combinations of CTLA-4 and PD-1/PD-L1 status (all p -values highly significant, e.g., p < 2.22e-16, F i g. 6 F–I), indicating enhanced potential response to immune checkpoint blockade.

Not only were the differences highly significant between each cell type (Mann Whitney Wilcoxon test, p < 2.22e − 16), but also the spatial order agreed with stereotypical tissue organization such that suprabasal cells were furthest away from smooth muscle cells, followed by basal cells and fibroblasts (Fig. 2 f).

Our second question: Did adaptation to the media or the presence of SA alter phage resistance? Our analysis revealed highly significant effects of both Treatment ( F = 132.73, df = 3, P < 2.22e-16) and Condition ( F = 41.83, df = 4, P < 2.22e-16) on the area under the growth curve, as well as significant Treatment × Condition interaction ( F = 37.66, df = 12, P < 2.22e-16).

As shown in Table 2 , the DOPE score exhibited a highly significant decrease ( t -test P = 2.36 × 10 −16 ; Mann–Whitney P = .000183), confirming a progressive enhancement in model stability and conformational quality across generations.

A Fisher's exact test shows that the association between sampling in China and pattern 1 is highly significant ( p <2.5 ̇10 −16 ).

These differences were highly significant: P = 2.5 × 10 −16 for the comparison between the optimum point and the conserved frequencies, and 3.1 × 10 −9 for the comparison between the optimum point and unbiased frequencies.

The resulting difference in phage genome abundance was highly significant (Fisher's exact test, p = 2.5 × 10 −16 ).

We found highly significant correlations between age and whole-brain grey matter density (VBM, P = 2.6 ∗ 10^− 16) and whole-brain cortical volume (SBM, P = 0.8 ∗ 10^− 9).

The markers BTA-76907-no-rs and ARS-BFGL-NGS-110734 had undefined positions on the genome and showed highly significant associations with κ-CN ( P = 2.80E-16) and β-CN ( P = 6.16E-15) (see Supplementary Table S1 ).

However, in a multivariate analysis there was a highly significant negative association between read depth of the expanded allele and expanded allele length ( r 2 = 0.632, p < 3 × 10 –16 , p ExpandedAlleleLength = 5 × 10 − 7 , n = 119).

This approach overcomes a problematic relationship we observed within the data: there was a highly significant correlation between ovary mass and body mass among queenless workers from all four colonies (Pearson correlation, R = 0.48, p = 3 × 10 −16 ; figure 3 a ).

Both main effects were highly significant (network: F 56,4 = 41.96, p=3.1e-16, η 2 p = 0.75; condition: F 28,2 = 22.27, p=2e-6, η 2 p = 0.61), while the interaction was not significant (p=0.29, η 2 p = 0.08).

Oleic acid content showed highly significant differences between the two species ( P ≤ 3.2 × 10 -16 ), yet NaCl had no significant impact on its levels ( P > 0.05) ( Fig 10c ).

However, a highly significant heterogeneity of effects ( P = 3·30 × 10 −16 [Cochran's Q]) prompted us to do IVW leave-one-out analysis to detect possible outlying genetic variants.

ARID2 also directly targeted a highly significant percentage of altered genes (46%, p-value = 3.4 × 10 −16 hypergeometric test).