Excerpts

The overlap is very highly significant (Fisher’s Exact Test: Odds Ratio: 9.38; p-value < 2.2e-16).

This difference is highly significant ( P = 2.21 × 10 −16 ), considering that the mean ARE score for human mRNA transcriptome is 3.8 ( Spasic et al. 2012 ).

Knocking out miR-983 caused a highly significant decrease in sperm length in D. melanogaster ( D. mel KO vs., D. mel WT: 1.724 ± 0.065 mm vs., 1.825 ± 0.047 mm; Wilcoxon rank-sum test, P < 2.22 × 10 −16 ; fig. 5 A ).

The spatial autoregressive parameter had a positive value and was highly significant ( p < 2.22 × 10 −16 ), indicating that endemism in a given area tends to increase with increasing endemism in surrounding grid cells (independent of the other parameters in the model).

RNA-seq showed highly significant overlap in gene expression between acute degradation of RAD21-TEV and genetic cohesin depletion in Rad21 lox/lox Nex Cre neurons (p<2.22e-16, odds ratio = 8.24 for all deregulated genes, odds ratio = 23.81 for downregulated genes; Figure 4a ).

Our second question: Did adaptation to the media or the presence of SA alter phage resistance? Our analysis revealed highly significant effects of both Treatment ( F = 132.73, df = 3, P < 2.22e-16) and Condition ( F = 41.83, df = 4, P < 2.22e-16) on the area under the growth curve, as well as significant Treatment × Condition interaction ( F = 37.66, df = 12, P < 2.22e-16).

There was a highly significant correlation between mRNA stability and translation levels across all genes (Spearman’s rho 0.2; p<2.22*10 −16 ) ( Figure 2F ).

Notably, the NecropImmScore strongly correlated with immunophenotype score (IPS), with high-score tumors exhibiting significantly higher IPS across all combinations of CTLA-4 and PD-1/PD-L1 status (all p -values highly significant, e.g., p < 2.22e-16, F i g. 6 F–I), indicating enhanced potential response to immune checkpoint blockade.

The samples were divided into two groups (normal group and tumor group) in TCGA-LUSC, and t -test on risk score of two groups showed quite significant in two groups (P<2.22e−16) (see Figure 6A ).

Not only were the differences highly significant between each cell type (Mann Whitney Wilcoxon test, p < 2.22e − 16), but also the spatial order agreed with stereotypical tissue organization such that suprabasal cells were furthest away from smooth muscle cells, followed by basal cells and fibroblasts (Fig. 2 f).

In this study, highly significant Pearson’s correlations ( p -value = 2.22 × 10 −16 ) among the mRNA expression of these genes were obtained (r ELOVL5-ELOVL6 = 0.90; r ELOVL5-SCD = 0.84; r ELOVL6-SCD = 0.86), supporting the involvement of common elements regulating their mRNA expression.

For log propodus height, there was no significant difference in the angle of slope between males and females (p = 0.078), but there was a highly significant difference in slope elevation when slope angles were assumed to be equal (p < 2.22 x 10 −16 ) ( Table 2 ), with males having broader log propodus heights than females throughout the size distribution of log carapace lengths ( Fig 5 ).

Pagel’s λ test indicated a very strong and highly significant phylogenetic signal (λ=0.99, P <2.22e-16), indicating that attC abundance is strongly structured by evolutionary history.

As shown in Table 2 , the DOPE score exhibited a highly significant decrease ( t -test P = 2.36 × 10 −16 ; Mann–Whitney P = .000183), confirming a progressive enhancement in model stability and conformational quality across generations.

A Fisher's exact test shows that the association between sampling in China and pattern 1 is highly significant ( p <2.5 ̇10 −16 ).

These differences were highly significant: P = 2.5 × 10 −16 for the comparison between the optimum point and the conserved frequencies, and 3.1 × 10 −9 for the comparison between the optimum point and unbiased frequencies.

The resulting difference in phage genome abundance was highly significant (Fisher's exact test, p = 2.5 × 10 −16 ).

We found highly significant correlations between age and whole-brain grey matter density (VBM, P = 2.6 ∗ 10^− 16) and whole-brain cortical volume (SBM, P = 0.8 ∗ 10^− 9).

The markers BTA-76907-no-rs and ARS-BFGL-NGS-110734 had undefined positions on the genome and showed highly significant associations with κ-CN ( P = 2.80E-16) and β-CN ( P = 6.16E-15) (see Supplementary Table S1 ).

This approach overcomes a problematic relationship we observed within the data: there was a highly significant correlation between ovary mass and body mass among queenless workers from all four colonies (Pearson correlation, R = 0.48, p = 3 × 10 −16 ; figure 3 a ).

However, in a multivariate analysis there was a highly significant negative association between read depth of the expanded allele and expanded allele length ( r 2 = 0.632, p < 3 × 10 –16 , p ExpandedAlleleLength = 5 × 10 − 7 , n = 119).

Both main effects were highly significant (network: F 56,4 = 41.96, p=3.1e-16, η 2 p = 0.75; condition: F 28,2 = 22.27, p=2e-6, η 2 p = 0.61), while the interaction was not significant (p=0.29, η 2 p = 0.08).

Oleic acid content showed highly significant differences between the two species ( P ≤ 3.2 × 10 -16 ), yet NaCl had no significant impact on its levels ( P > 0.05) ( Fig 10c ).

However, a highly significant heterogeneity of effects ( P = 3·30 × 10 −16 [Cochran's Q]) prompted us to do IVW leave-one-out analysis to detect possible outlying genetic variants.

Using Pearson’s χ 2 test, we found the difference to be highly significant ( p = 3.4 × 10 −16 ), possibly suggesting a selection against the G/G (CFA5 locus) T/T (FructoCFA3) genotype combination.