Barely Significant

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highly significantp = 1 × 10 ‐ 80.0× alphaqualifiedgold
There was no significant difference in the family effect between years (interaction family × year not significant; LRT: χ 2 = 1.2; df = 2; p = .552), but the family effect was highly significant ( χ 2 = 32.6; df = 1; p = 1 × 10 ‐ 8 , Table S2 ) and the heritability of the sensitivity to vernalization was 0.19 (±0.04) (Table 2 ).
highly significantp <10 −80.0× alphaqualifiedgold
Statistical analysis showed that the increase in inter-click angle was highly significant ( Figure 2A , bottom: one-way ANOVA: F >71, p <10 −8 ; post-hoc t tests: p <10 −11 for comparing one-object experiments after locking versus no-object experiments; p <10 −6 for multiple-object experiments after locking versus one-object after locking).
highly significantP -value < 1 × 10 −80.0× alphaqualifiedgold
Compared to peaks containing L-CTCF-BSs, P-CTCF-BSs exhibited a higher mutation rate of 1.34 and 1.25 times per CTCF-BS for LNCaP and MCF7 respectively ( Supplementary Table S4 ), and the elevated rate is highly significant ( P -value < 1 × 10 −8 ) as determined by a permutation test (Materials and methods) (Figure 2A , B ).
highly significantp < 10 −80.0× alphaqualifiedgold
The univariate ANCOVA model applied (equation 2 ) revealed very highly significant differences between (1) the culinary oils investigated ( p < 10 −8 , with the exception of cis -2-alkenals for which p = 4.85 × 10 −3 ), and (2) sampling time-points ( p < 10 −8 ) for all aldehydes monitored.
highly significantp < 10 −80.0× alphaqualifiedgold
While we found no obvious and consistent correlations between GWAS gene significance and FCs (electronic supplementary material, figure S4 a–g ), we identified GRIN2A and KCNB1 with highly significant GWAS associations ( p < 10 −8 ) in all seven diseases, and more strongly upregulated TL (FDR < 0.05, log 2 FC (TL/FL) > 1) in either both INH/EX ( GRIN2A ) or in INH ( KCNB1 ) ( figure 1 f,h ).
highly significantP = 1 × 10 −80.0× alphaqualifiedgold
A burden test adjusted for sex and the first five principal components for the 15 loci revealed highly significant enrichment in rare homozygous, potential compound heterozygous, or hemizygous variants in patients relative to controls (P = 1 × 10 −8 ; odds ratio = 26.6; 95% confidence interval = 7.3–96.6), with 12 carriers among the patients (10.7%, including four homozygotes, one potential compound heterozygote, and seven hemizygotes) vs. three (0.25%, two homozygotes, one hemizygote) among the controls.