Excerpts

S4b ), we found a highly significant peak on chromosome 17 (Fig. 6a , Supplementary Data 5 and 6 ) where the lead variant was an intergenic SNP upstream of the BMP2 gene (chr17:15643342:C>T, P = 3.45 × 10 − 39 ).

4c ) show that the TE and ICM nuclei in blastocyst embryos have highly significant differences in the mean nuclear dry mass density ( p -value = 8.11e−39), while the differences for cleavage state embryos are nonsignificant ( p -value = 0.0105).

Using a logistic regression model, we found that several factors had a highly significant influence on whether a proximal eQTL was detected as an aiQTL; namely, the distance of the eQTL from the TSS (P = 1 × 10 − 38 ), the number of samples with more than one allele-specifically mapped read (P = 1 × 10 − 88 ), the log P value of the eQTL (P = 3 × 10 − 174 ), the minor allele frequency of the eQTL (P = 2 × 10 − 44 ) and the median number of allele-specifically mapped reads (among samples with more than one allele-specifically mapped read; P = 0.008).

GO enrichments for the lightgreen module are highly significant for “secretory granule” (p=2.14E-38), “secretory vesicle” (p=1.96E-36), and different specific neutrophils-associated terms such as “neutrophil activation involved in immune response” (p=1.04E-35), “neutrophil degranulation” (p=1.04E-35), “neutrophil activation” (p=2.00E-35), and “neutrophil mediated immunity” (p=2.64E-35).

We measured the relative abundance of the total ether-linked lipids and observed a highly significant elevation ( p -value = 2.94E-38) of total ether-linked lipids at 48 h post virus infection ( Figure 5C ).

A highly significant S-PrediXcan signal ( p = 6.10e–38) was also obtained for this WDR19 intron cluster in testis, however the evidence for colocalization with the GWAS peak was low (PP.H4.abf = 0.39).

We observed a highly significant correlation ( R 2 = 0.5086, p = 8.5e−38; data not shown).

Examination of the proteins with reduced abundance in the sod-1 mutant showed a highly significant enrichment of ribosomal proteins ( p < 10 –37 ) including 24 RPL proteins, which are in the large 60S ribosomal subunit ( Figure 6 C, Table S6 ).

Another study [ 8 ] reported that infection rates are higher in metropolitan cities with large population density in India as they found a fair and highly significant correlation ( r = 0.49, p-value ~ 10 −37 ) at the 5% level of significance.

The difference was highly significant (Mann–Whitney p = 1.0E–37); (2) location of matching regions: In non-seed-binding miRNAs/isomiRs, we observed that over half of the matching regions began between positions 6 and 8.

The Jaccard similarity coefficients and the highly significant p -values (hypergeometric test p < 1 × 10 −37 in all cases) of the overlap of the top upregulated genes in DN and the GNs indicated that upregulated genes were common not only among FSGS, MN and IgAN, but also among DN and the three GNs ( Figure 1B ).

Fraction Csp3 showed highly significant correlations with Molar Refractivity (p = 1.7613E-37), MolVol (A3) (p = 4.2254E-26), and Druglikeness score (p = 9.35371E-33), while exhibiting marginally significant associations with TPSA(Å 2 ) (p = 0.059100432) and MolPSA (A2) (p = 0.055785406).

Our results ( Figure 5b ) show a highly significant correlation (Fisher's exact test: p -value < 1*10 −36 ) between a nearby marking event and the decision to remove the adjacent bead. 3.5 The effect of pheromone marks and recruitment on context sensitivity Since pheromone markings act as triggers for the clearing behavior, we tested whether the marking rates could explain the context sensitivity described above (Methods and Figures 3d – g ).

The correlation between mean catch-up saccades per second and microsaccades rate was moderate, with a Pearson correlation coefficient of r = 0.58, a 95% confidence interval of [0.51, 0.64], and a highly significant p-value ( p = 1.99e-36).

Coexpression of CD47 and IFT57 mRNAs Is Intrinsic to Cancer Cells A highly significant positive correlation was also observed between CD47 and IFT57 mRNA expression across the 1156 cell lines in the Cancer Cell Line Encyclopedia (CCLE) [ 26 ] ( p = 4.6 × 10 −36 , Table 1 , Figure 1 d).

The correlation of IVW analysis is highly significant (β = −0.16, P = 5.91 × 10 −36 ).

The overlap of the downregulated genes in strains overexpressing the D303A or D346A variants compared to those in the strain overexpressing wild-type RNase E was statistically highly significant ( P < 10 –35 and < 10 –46 , respectively, hypergeometric test).

The results showed pathways involved in repairing damaged nucleotides/DNA as highly significant in determining alkylating agent sensitivity: the Fanconi anemia pathway, ( p = 1.04 × 10 −35 ), homologous recombination (2.00 × 10 −24 ), nucleotide excision repair (2.77 × 10 −9 ), and non-homologous end-joining (1.04 × 10 −7 ) ( Figure 6 ). 3.

Of note, in agreement with the known relationship between ΔAUC CP /ΔAUC GLU and GLUSENS in the general population, in our population of renal transplant patients, we also observed a quite high correlation between the two, as mirrored by the highly significant p -value ( p = 2.22 × 10 −35 ).

The different response to hc‐IEDs for sample entropy and delta power was highly significant ( p = 6.3 × 10 −35 , Wilcoxon rank‐sum test).

In the liver, six highly significant modules were identified ( Figure 4 A–D and Figure S6 ): MEbrown (cor = 0.85, p = 2.3 × 10 −34 ; transcripts no. = 119), MEblack (cor = 0.83, p = 1 × 10 −200 ; transcripts no. = 925), MEcyan (cor = 0.54, p = 0.0012; transcripts no. = 33), MEsalmon (cor = 0.63, p = 8.5 × 10 −05 ; transcripts no. = 33), MEgreen (cor = 0.68, p = 3.1 × 10 −22 ; transcripts no. = 154), and MEgreenyellow (cor = 0.34, p = 0.049; transcripts no. = 34) ( Figure S7A–F and Figure 4 E–K).

A second, highly significant set of associated variants in 1q32.2 was defined by the lead SNP rs570516915 ( P = 5.25 × 10 –34 , OR = 8.65, Fig. 2b ).

Other highly significant pathways included skeletal system development ( p = 8.431 × 10 −34 ), cartilage development ( p = 8.904 × 10 −34 ), and ossification ( p = 1.231 × 10 −33 ).

This analysis revealed a novel variant, rs148726219, located on chromosome 19q13.32 (>500 kb from APOE ) which showed highly significant association with AD in DF3 (p = 8.9e-34, OR = 2.5) and had further increased significance in the later release DF6 (p = 2.7e-54).

Further analysis of the differentially methylated probes in all primary human keratinocytes from 13 different donors also showed a moderate, but robust and highly significant ( p = 1.4 × 10 −33 , t -test) reduction of DNA methylation in the DHM-treated cells ( Figure 2B ).