Excerpts

The ANN achieved an F-statistic value of 432.7, indicating a highly significant model fit with a practically negligible probability of F-statistic ( p < 6.06 × 10 −46 ).

Furthermore, we also confirmed there was a highly significant correlation between Module membership (Mm) and Gene significance (GS) in these modules (black module: Cor = 0.51, p = 1.4e−45 (Fig. 3 A); brown module: Cor = 0.7, p = 1.2e−148 (Fig. 3 B); magenta module: Cor = 0.5, p = 9.8–11e (Fig. 3 C)).

Of note, a highly significant association (− log 10 P = 44.79) for ‘seed: colouration with phenol’ on chromosome 2A was just 0.37 Mb from the Ppo-A1 gene known to control discolouration in wheat food products.

Analysis using the GEPIA database revealed a highly significant correlation ( p = 2e -45 , R = 0.82) between these markers, providing new insights into the molecular mechanisms underlying PAAD progression and identifying new targets for diagnostic and therapeutic strategies.

MMP14 exhibited a marked increase in expression in tumor tissues, with a highly significant difference between normal and cancer groups ( p = 4.9 × 10 −45 ).

Among 11 prototypical sarcomere genes, 10 displayed highly significant isoform shifts (p = 5.23 × 10 −45 –2.89 × 10 −200 ).

A chi‐square test confirmed that this enrichment was highly significant ( p = 1.1357 × 10 −44 ), underscoring the prominent role of DNA transposons in gene regulation.

A highly significant overall association between PRS and COVID-19 infection was shown for the White ethnic group ( p = 8.69 × 10 –44 , < 0.0001).

Subsequent memory effects in selective neurons Due to the preceding screening procedure, we found highly significant fractions of neurons responding selectively to one or more items in all recorded brain regions (all P < 10 –43 , binomial test, one-sided with n = total number of neurons per region, k = number of responsive neurons per region, P = 0.001, corresponding to the alpha level of our response criterion, refer to “item responses”, Fig. 2 , Fig.

A total of 18 SDRs were identified across the genetic maps, primarily located on LG1–LG4, LG6, and LG8, with LG8 and LG3 containing 5 and 4 SDRs respectively, Strong collinearity between the genetic map and physical assembly was confirmed by highly significant Pearson correlations (R = −0.84 to 0.83; P = 10 −43 to 10 −217 ) for marker positions across all nine chromosomes ( Table S9 ; Fig.

26 , 28 - 31 A subsequent meta-analysis, which included 5,159 patients with AIS and 17,840 controls, reported a highly significant association with this SNP, with a P = 1.22 × 10 -43 for both men and women, and an even stronger P = 2.94 × 10 -48 for women only. 32 The present study established a significant association between the LBX1 polymorphism rs11190870 and AIS susceptibility ( P < .001), consistent with prior research conducted across diverse populations, particularly in East Asian cohorts.

To compare our findings to a genetic variant with known association with neurodegenerative diseases and aging, we made similar analysis with the frequencies of APOE ε4 allele, which showed a highly significant decrease with age ( p = 3 × 10 −43 ).

The concordance between SomaModules and the optimal WGCNA clustering is highly significant (Fisher’s exact test p -value = 10 –42 ).

There is also a mild but highly significant correlation between the total number of targets involved in a combination and percentile of cell lines in which it is synergistic (Spearman’s ρ = 0.21, P = 6.25 × 10 −42 ), (Fig. 6A ).

This result is highly significant (p=10 –41 , exact ranks test, MATLAB signrank ) and holds for all tested pitch classes in the pair ([0,3,6,9], Figure 4D ).

Chi-square tests yielded the most highly significant results for terpenoids ( p = 1.2 × 10 −41 ), amino acids and derivatives ( p = 1.6 × 10 −35 ), flavonoids ( p = 3.1 × 10 −33 ), lipids ( p = 4.8 × 10 −15 ), flavonols ( p = 1.8 × 10 −12 ), phenolic acids ( p = 2.6 × 10 −12 ), and flavones ( p = 1.1 × 10 −11 ). 3.2.

Although Aβ and tau oligomer levels showed a highly significant correlation (Spearman r = .541, p = 2.7 × 10 −41 ), no increase of tau oligomer levels regarding the disease stage was observed (Figure 1B ).

A highly significant association was found between the two tests ( p = 6.09 × 10 −41 ).

When normalized, manual analysis accuracy for N-T tissues increased from 0.75 to 0.91, which was highly significant (p=7,72x10 -41 ).

Other miRNAs were not ranked at the top 30 of comparative activity mode (Methods), however they show highly significant differential activity (corrected WRS p -value < 1 e −40) and substantial activity in at least one of the populations (activity p -values below 1 e − 4 among at least third of cells in at least one population).

The 6 most highly significant smoking CpGs were also the most highly associated with bladder cancer (smoking p -value < 10 - 40 , bladder cancer p -value < 10 - 10 ).

Notably, dipeptides, such as Val-Glu and Met-Gln, showed highly significant values in AP ( p -value > 10 −40 ) ( Figure 3 ).

We found a large (n = 98) and highly significant (p = 2.8e−40) overlap between the splicing events regulated by QKI and RBFOX2 ( Figure 4 D).

Intima-Media Thickness and Genetic OAG Risk First, we validated the association between the OAG-GRS and OAG, which was highly significant ( P = 4.8 * 10 −40 ), with an OR of 2.44 (95% CI = 2.13–2.78) for each standard deviation increase in OAG-GRS.

A highly significant reduction ( p = 2.3 × 10 –39 ) in the number of Candida colonies was observed in the treatment arm when comparing pre- and post-study results.