Excerpts

The HLA profiles of the two diseases were positively and highly significantly correlated ( Figure 5 ) (r = 0.904, P = 6.4 × 10 −48 , N = 127).

When restricted to the 3,137 EUR cases with a PheCode probability >0.80 and their 12,548 matched controls, the 90-SNP weighted PRS was highly significant (odds ratio [OR] = 1.82 [95% confidence interval: 1.68–1.97]; p = 8.0 x 10 −48 ).

A statistical comparison using Cochran's Q test revealed highly significant differences among the models (Q = 235.5, df = 7, p = 3.27E-47).

With a global average of 52.7% ± 0.12% history-congruent trials, we found a small but highly significant perceptual bias towards preceding experiences ( β = 16.18 ± 1.07, T(1.09×10 3 ) = 15.07, p = 10 −46 ; Fig 2A ) that was largely consistent across studies ( S1B Fig ) and more pronounced in participants who were less sensitive to external sensory information ( S1C Fig ).

Circulating T cell fraction remained highly significant after adjusting for clinical factors in the pan-cancer cohort (Fig. 5b (HR = 0.76, P = 2.6 × 10 −46 ) and Extended Data Fig. 9a ) and within five individual cancer types after multiple hypothesis correction—head and neck squamous cell carcinoma (HR = 0.70, adjusted P = 4.68 × 10 −2 ), pancreatic adenocarcinoma (HR = 0.74, adjusted P = 4.81 × 10 −2 ), colon adenocarcinoma (HR = 0.85, adjusted P = 1.12 × 10 − 2 ), lung adenocarcinoma (HR = 0.80, adjusted P = 5.4 × 10 −3 ) and sarcoma (HR = 0.68, adjusted P = 1.57 × 10 −4 ).

A highly significant association was observed between BMI and triglyceride levels (Beta = 0.26, p = 3.06E-46), and a positive correlation trend was also seen between BMI and UA.

These represent 41% and 33% of upregulated phosphoproteins in OCMI91s and OVCAR8 cells, respectively - a highly significant overlap by hypergeometric test (enrichment 3.0-fold; p = 4x10 -46 ).

The ANN achieved an F-statistic value of 432.7, indicating a highly significant model fit with a practically negligible probability of F-statistic ( p < 6.06 × 10 −46 ).

Furthermore, we also confirmed there was a highly significant correlation between Module membership (Mm) and Gene significance (GS) in these modules (black module: Cor = 0.51, p = 1.4e−45 (Fig. 3 A); brown module: Cor = 0.7, p = 1.2e−148 (Fig. 3 B); magenta module: Cor = 0.5, p = 9.8–11e (Fig. 3 C)).

Of note, a highly significant association (− log 10 P = 44.79) for ‘seed: colouration with phenol’ on chromosome 2A was just 0.37 Mb from the Ppo-A1 gene known to control discolouration in wheat food products.

Analysis using the GEPIA database revealed a highly significant correlation ( p = 2e -45 , R = 0.82) between these markers, providing new insights into the molecular mechanisms underlying PAAD progression and identifying new targets for diagnostic and therapeutic strategies.

The paired change was highly significant (McNemar’s χ 2 (1) = 198.89, p < 3.65 × 10 −45 ) ( Figure 4 ).

MMP14 exhibited a marked increase in expression in tumor tissues, with a highly significant difference between normal and cancer groups ( p = 4.9 × 10 −45 ).

Among 11 prototypical sarcomere genes, 10 displayed highly significant isoform shifts (p = 5.23 × 10 −45 –2.89 × 10 −200 ).

A chi‐square test confirmed that this enrichment was highly significant ( p = 1.1357 × 10 −44 ), underscoring the prominent role of DNA transposons in gene regulation.

A highly significant overall association between PRS and COVID-19 infection was shown for the White ethnic group ( p = 8.69 × 10 –44 , < 0.0001).

A total of 18 SDRs were identified across the genetic maps, primarily located on LG1–LG4, LG6, and LG8, with LG8 and LG3 containing 5 and 4 SDRs respectively, Strong collinearity between the genetic map and physical assembly was confirmed by highly significant Pearson correlations (R = −0.84 to 0.83; P = 10 −43 to 10 −217 ) for marker positions across all nine chromosomes ( Table S9 ; Fig.

Subsequent memory effects in selective neurons Due to the preceding screening procedure, we found highly significant fractions of neurons responding selectively to one or more items in all recorded brain regions (all P < 10 –43 , binomial test, one-sided with n = total number of neurons per region, k = number of responsive neurons per region, P = 0.001, corresponding to the alpha level of our response criterion, refer to “item responses”, Fig. 2 , Fig.

26 , 28 - 31 A subsequent meta-analysis, which included 5,159 patients with AIS and 17,840 controls, reported a highly significant association with this SNP, with a P = 1.22 × 10 -43 for both men and women, and an even stronger P = 2.94 × 10 -48 for women only. 32 The present study established a significant association between the LBX1 polymorphism rs11190870 and AIS susceptibility ( P < .001), consistent with prior research conducted across diverse populations, particularly in East Asian cohorts.

To compare our findings to a genetic variant with known association with neurodegenerative diseases and aging, we made similar analysis with the frequencies of APOE ε4 allele, which showed a highly significant decrease with age ( p = 3 × 10 −43 ).

The concordance between SomaModules and the optimal WGCNA clustering is highly significant (Fisher’s exact test p -value = 10 –42 ).

There is also a mild but highly significant correlation between the total number of targets involved in a combination and percentile of cell lines in which it is synergistic (Spearman’s ρ = 0.21, P = 6.25 × 10 −42 ), (Fig. 6A ).

This result is highly significant (p=10 –41 , exact ranks test, MATLAB signrank ) and holds for all tested pitch classes in the pair ([0,3,6,9], Figure 4D ).

Chi-square tests yielded the most highly significant results for terpenoids ( p = 1.2 × 10 −41 ), amino acids and derivatives ( p = 1.6 × 10 −35 ), flavonoids ( p = 3.1 × 10 −33 ), lipids ( p = 4.8 × 10 −15 ), flavonols ( p = 1.8 × 10 −12 ), phenolic acids ( p = 2.6 × 10 −12 ), and flavones ( p = 1.1 × 10 −11 ). 3.2.

Although Aβ and tau oligomer levels showed a highly significant correlation (Spearman r = .541, p = 2.7 × 10 −41 ), no increase of tau oligomer levels regarding the disease stage was observed (Figure 1B ).