Excerpts

When the imbalances observed in our samples at the SNPs rs6983267 , rs961253 , rs3802842 , rs10411210 , rs4444235 , rs4779584 , and rs9929218 were combined with those published previously [19] , [35] , we observed a highly significant relative loss of the non-risk T allele of rs6983267 (p-value = 2.94×10 −5 ).

The dust sheet test 2–3 h showed the highest correlation with the reference method with the data points scattered closely around the regression line and the slope being highly significant ( p = 0.00003).

Compared to the untreated control, both treatment protocols resulted in a highly significant reduction in viable cell counts (t-test, t (5) = 14.30, p = 0.00003, ***), corresponding to a ~ 4 log10 reduction (Figs. 6 and 7 ).

Nonetheless, the difference in tumor growth between +dox and -dox was highly significant ( p = 0.00003).

However, the KNN classifier trained on the exonic subset of features showed no statistically significant difference in BCR-free survival using a log-rank test ( p < 0.08) whereas the difference was highly significant for the non-exonic KNN classifier ( p < 0.00003).

Highly significant differences were seen in plasmacytoid DCs (pDCs) (mock primed: 56.4±1.6; ArmΔGPC primed: 30.2±1.7, p = 0.00003), macrophages/monocytes (mock primed: 11.4±1.6; ArmΔGPC primed: 2.1±0.6, p = 0.0017) and FRCs (mock primed: 9.0±0.4; ArmΔGPC primed: 1.7±0.3, p = 0.000007) from primed and mock primed Cl13 infected mice ( Fig. 6A ).

filters F3+F4; 365 SNPs in 396) (Table 3 ), a highly significant difference was found in the final number of SNPs recovered with call rates ≥ 95%, (Chi-square Pearson = 17.40; p = 0.00003).

The difference in the GPi cell firing frequency across the groups was highly significant ( figure 2 C p=0.00003).

Consistent with this, regression of second component dopamine responses to cues (0.2–0.6 s after the cue onset) onto value estimates of the superior model was highly significant ( Figure 4B , right, R 2 = 0.93, p=0.00003).

FI was the most highly significant factor between patient groups with a good and poor outcome ( P =0.00003, independent groups t -test, t =−4.38, df 98).

Within the case group, a Jonckheere–Terpstra test for trend (based on 100,000 permutations) revealed a highly significant increasing trend across the three age strata (puppy, juvenile, adult; JT = 166.5, p = 3 × 10 −5 ) with the median VBI increased from 0.48 (puppy) to 0.55 (juvenile) and 0.57 (adult).

Three significant loci were identified by this analysis ( P < 0.000002), along with a fourth marginally significant ( P < 0.00003).

We reported co-occurring mutations in TP53 and PTEN , and in PIK3CA and TP53 , and a highly significant enrichment for trios of co-occurring mutations in TP53, PIK3CA , and PTEN (n = 3/30; P = .00003) as compared with TCGA (The Cancer Genome Atlas) breast cancer exome sequence data.

Symptom prevalence The most frequently reported symptom among patients with uterine isthmocele was AUB, observed in 45 cases (78%), which showed a highly significant association (p = 0.00003).

Regarding the comparison of IGRA results in disseminated versus other forms of tuberculosis, a previous multicenter study using data from collaborators from mainly high-income European countries found that in children with microbiologically confirmed tuberculosis IGRA sensitivity, when results were pooled for different versions of IGRAs ,was 70% (56/79) in those with disseminated versus 89% (283/315) in those with pulmonary tuberculosis, which we calculated was a statistically highly significant difference ( p = 0.00003).

In all cases, there was a clear bias of propagation in one orientation, which was highly significant ( P < 3 * 10 −5 ; 12 retinas aged P4–6; data not illustrated).

Association analysis in Hanoverian stallions In 216 Hanoverian stallions, a nominally significant association with de-regressed EBV-PAT was found for the NOTCH1 variant g.37455302G>A ( P = 0.00003) using a model fitting the genotypes.

When we compare SO 2 values with HbO 2 double peaks the difference was highly significant ( P = 0.00003).

This highly significant enrichment of S-aromatic motifs within the low-reactivity group (p-value = 3 × 10 −5 ), allows us to conclude that the involved methionines exhibit a much lower reactivity than their non-interacting counterparts.

Compared with population data, enrichment of SIX1 loss-of-function variants was highly significant (p=0.00003).

This differences in the percentage of infections were highly significant when compared by chi-square test (Pearson’s chi-square = 17.231; p -value = 0.00003).

Furthermore, we also confirmed there was a highly significant correlation between MM and GS in this module (Cor = 0.47, p =3 e − 05) ( Figure 3(d) ).

In particular, CM-CF showed highly significant differences compared with U-CF ( P value = 0.00003), indicating a positive effect of the combination of mercerization and coating on CF stiffness.

Under this null model, there was a highly significant increase in the proportion of missense mutations on the ligand-binding interface (Fig. 3e , expected = 43%, observed = 64%, p = 3e −5 , n = 107, two-tailed binomial test, Supplementary Note 10 ).

This difference is highly significant ( P = 0.00003), calculated using a χ 2 test. 10 Financial disclosures are summarized in Table 1 .