Excerpts

This increase in cervicovaginal disease severity was highly significant ( P = 9.53 × 10 −5 ) compared to mice infected with MmuPV1 but not treated with UV and E2.

There was also a positive, highly significant association between older age and improvement of baseline social functioning, i.e., per year of age, social functioning would increase by 53% (ß = 0.53, p = 9.53 × 10 −5 ); see Figure 4 .

We observed minimal but statistically highly significant differences in cfDNA yields between blood samples stored in EDTA or PAXgene tubes (p=0.000097, paired t-test).

All the probes shown in Figure 2 were highly significant with p-values <9.77E −05 .

Interestingly, in our study, both the pangenome- and SNP- based GWAS analyses indicated that the rimI gene, encoding a ribosomal protein S18-alanine N-acetyltransferase, is linked to clinical traits displayed by the isolates, as indicated by a significant pangenome locus (adjusted p-value < 0.00033) and two highly significant SNPs (adjusted p-value < 9.7979e-05).

Sensitivity analyses’ results In addition to the IVW method, the WM method also showed a marginally positive significant association between total lipids in S.HDL.L and UC (OR = 1.201, 95% CI: 0.994–1.451, P = 0.052) [ Table 2 ], although this association did not reach statistical significance at a Bonferroni-corrected threshold ( P < 9.94 × 10 −5 ).

In contrast, a previous meta-analysis of GWAS with a comparable sample size (∼ 30,000) reported that SNP rs1831554 within this locus showed marginal significance for femoral neck BMD ( P = 9.94 × 10 −5 ) and lumbar spine BMD ( P = 1.41 × 10 −4 ) [ 8 ].

Monte Carlo simulations show that LAD formation on preexisting GADs is not random, but is rather highly significant ( P = 9.98 × 10 −5 ) ( Fig. 5 B).

Group classification using the support vector machine (SVM) Overall, the set of 12 variables achieved good classification accuracy (81%), sensitivity (78%), and specificity (85%), and each of these were highly significant compared to chance simulations using permutation tests (accuracy P = 9.99 × 10 −5 ; sensitivity P = 9.99 × 10 −5 ; specificity P = 6.99 × 10 −4 ).

Intriguingly, the let-7g targets showed highly significant enrichment for association signal ( p = 9.99 × 10 −5 ) and magnitude signal ( p = 3 × 10 −4 ) in comparison with non-target genes based on quartile categorization.

The dissimilarity metrics, measured separately with Bray-Curtis, Jaccard, and Jensen-Shannon (JSD) indices with 10,000 permutations, were all highly significant (PERMANOVA, p = 9.999e-05), representative of the centroids being different between the two groups.

Beta diversity among sampling years was highly significant for all bird species ( n = 167, R = 0.175, P = 9.999e −05 ; Supplementary Fig. 8c ) and when subsetting by only sandhill cranes ( n = 122, R = 0.106, P = 9.999e −05 ), but not when subsetting for only non-crane bird species ( n = 45, R = −0.70, P = 0.905).

In contrast, there was a highly significant reduction in the percentage of w AlbB2-Dhaka mosquitoes with virus detected in legs and wings (52.4%, n = 21, Fisher’s Exact test, p < 0.0001) (Fig. 6 B).

For MALAT1, the mean expression for SAH patients without CVS was 1.25 with 0.40 SD, whereas that for SAH patients with CVS was 2.76 with 0.77 SD, and the statistical difference between the groups was highly significant (p < 0.0001) ( Figure 1 ).

The difference was highly significant (P < 0.0001) when all three cohorts shown in Figure 3 (RA, SLE, HC) were simultaneously compared.

After stratification by plurality of birth, somewhat weaker but still highly significant associations of ART with ARM were seen among both singletons (OR, 7.7; 95% CI, 4.6–12.7; P < 0.0001) and multiple births (OR, 4.9; 95% CI, 2.4–10.1; P < 0.0001) (Table 5 ).

The Kruskal–Wallis test demonstrated a highly significant difference in SUV mean across age groups in males (H = 25.46, p < 0.0001), with a trend in females (H = 8.52, p = 0.074).

The a priori defined primary pharmacodynamic outcome of an increase in the frequency of Tregs as a percentage of CD4 + T-lymphocytes at D8 was dose-dependent (JT-J test, p < 0.0001) and highly significant for both treated arms (MW-U test, p < 0·0001; 2 MIU: mean [SD]: +6·2% [2·2]; 1 MIU: mean [SD]: +3·9% [1·2]) as compared to placebo (mean [SD]: −0·5% [1·3]) (see Table 3 , Fig. 2 a and b).

The quadratic term for age (Age 2 ) was highly significant (β = 0.0021, SE = 0.0002, 95% CI [0.0018, 0.0025], p < 0.0001), accounting for 77.7% of heterogeneity, which indicates a non-linear effect across the age range (∼42–70 years).

The interaction between medium, forage and dose and the interaction between medium, forage and time were also both highly significant ( P < 0.0001). 4.

Comparative analysis of gene polymorphisms in groups of patients with adverse clinical and laboratory data by Plinc programme revealed highly significant differences in higher carriage of minor unfavourable alleles in the group with hyperleukocytosis for rs1800630 polymorphism in TNF gene (p<0.0001; OR1=3.943) ( Table 3 ).

Statistical analysis (ANOVA, p < 0.05) revealed highly significant differences ( p < 0.0001 for most pathogens, and p = 0.003 for Morganella morganii ) in biofilm formation among the untreated control, hibiscus-treated, and prune-treated groups for nearly all the examined isolates.

Exclusion of SNPs showing a significant trend (with p<0.0001) reduced the set further to 5609 SNPs.

Although there was an increasing trend from Process A (3.6 ± 0.5%) to Process B (7.9 ± 1.1%, p < .0001, compared to Process A) to Process C (9.5 ± 3.0%, p = .11 compared to Process A, p = .53 compared to Process B), the trend was not consistently statistically significant.

This difference is highly significant (p = 0.0001), confirming the better tolerance of anticoagulant treatment with LMWH.