Mir-148a-3p exhibited a highly significant modification with a p -value < 0.0001, while mir-106a-5p had a p -value of 0.0168 when comparing the PCa group versus the BHP group.
Excerpts
The overall model was highly significant, with an exceptionally low p-value ( p < 0.0001) and a high F-statistic (F = 95.87).
There was a highly significant difference in long-term graft survival between these two groups (log-rank test p < 0.0001); Figure 3 . 4.
14 of the 23 proteins correlated significantly with estradiol whereof sTNFRSF4, -6B, TNF, TNFSF14 and sTNFRSF10B being highly significant, p<0.0001, Figure 5B .
Together with the highly significant differences (Two‐tailed paired t ‐test P < 0.0001; n = 65) in the average (±SD) counts of unique gene clusters obtained from complete versus complete plus partial gene catalogues ( Supplementary Data 1 ) suggests a strong effect of partial gene sequences on gene diversity, and in turn, gene discovery.
There is a highly significant association between L2 and disease-group distribution (Chi-Square p < 0.0001).
The post hoc Tukey’s test shown in Figure 5 provides strong statistical evidence for this cytotoxic effect, particularly at 100 μg/mL, which showed highly significant reductions in cell viability ( p < 0.0001).
The simulation group showed an extremely significant (two-tailed p < 0.0001) improvement in their post-test scores when compared to their scores before the module was taught.
By two-tailed t-test, all markers exhibited highly significant (P<0.0001) decrements in immunoreactivity in the AD twin compared to the ND twin ( Figure 2b ).
In HEK293 cells with β-arrestin knocked out, there was a significant trend towards increasing the potency when β-arrestins were knocked out ( p < 0.0001) ( Figure 4B , Supplementary Table S6 ).
In this study investigating affective disorder patients, there was also a highly significant positive correlation (τ = 0.15, p < 0.0001, n = 788) between the total Hamilton score and the total CTQ-score as we already reported previously [ 27 ].
The association of the modified PHQ with fatigue was also highly significant (3 months: ß = 0.59, p < 0.0001; 12 months: ß = 0.72, p < 0.0001).
These gradients were highly significant ( P < 0.0001), independent of malignancy and robust to neighbourhoods of diverse radii (Extended Data Fig. 3g,h ).
We found a statistically highly significant difference between the two patient groups ( p < 0.0001), reflecting a good discriminant validity.
Tiger caregivers in private facilities all had direct contact with the young tigers provided for the tourists, whereas none of the caregivers in government facilities had direct contact with tigers: a highly significant difference despite the small number of tiger caregivers ( p < 0.0001).
* indicates p -value 0.01 to 0.05 (significant), ** indicates p -value 0.001 to 0.01 (very significant), *** indicates p -value 0.0001 to 0.001 (extremely significant), **** indicates p -value p < 0.0001 (extremely significant), ns indicates p ≥ 0.05 not significant. 3.
The statistical significance and adequacy of this quadratic model were confirmed by Analysis of Variance (ANOVA), as detailed in Table S3 , which showed a highly significant model ( P < 0.0001) and a non-significant lack of fit ( P = 0.3012).
As in Kaplan-Meier analysis for the clusters identified by our method in METABRIC, an extremely significant survival difference was found among intrinsic subtypes with a log-rank p < 0.0001, showing the worst survival rate for basal subtype.
Moreover, given the highly significant differences in the changes of the apoptotic marker Cleaved-Caspase3 across groups following CypD expression modulation (both P < 0.0001), it is suggested that cell death may be the primary cause of the decline in cell viability.
There was a highly significant increase in the vascular staining in both groups with DPN compared to the HV group (painful-DPN, p < 0.0001; painless-DPN, p = 0.0037), and also in the No-DPN group ( p = 0.02), compared with the HV group.
There was a highly significant relationship between larval mortality ( p < 0.0001) and the total percentage of pupae formed ( p < 0.0001) both among concentrations and among different samples of Au-doped ZnO.
Both main effects were also highly significant for Group: F(2, 228) = 52.02, p < 0.0001 (22.84% of variation) and Tissue region: F(2, 228) = 49.99, p < 0.0001 (21.95% of variation).
By this criterion, the fraction of cells exhibiting λ R /RAD51 colocalizations is not significantly different from background, while the fraction of cells exhibiting colocalizations of RAD51D-GFP or XRCCC2-GFP is highly significant ( P = 0.0001, χ 2 test).
KM analyses revealed highly significant differences between overall survival times of the high-risk and low-risk groups (P < 0.0001) ( Figure 6 ).
The correlation is statistically highly significant ( p < 0.0001).