Excerpts

A p < 0.05 (*) was considered statistically significant; p < 0.01 (**) highly significant; p < 0.001 (***) extremely significant; p < 0.0001 (****) highly extremely significant. 5.

In addition, the expression levels of SLIT2 and EZH2 showed a highly significant ( r < −0.4; P < 0.0001) anti-correlation supporting EZH2 repression of SLIT2 in vivo ( Figure S6 ).

Box plots for the results of A , showing highly significant difference ( p <0.0001).

In discrete time survival analyses, lower baseline UPSIT scores were associated with transition to AD (hazard ratio 1.099 per point interval; 95% CI: 1.067, 1.131; P <0.0001) and remained highly significant (hazard ratio 1.072 per point interval; 95% CI: 1.036, 1.109; P <0.0001) after including demographic, cognitive, and functional covariates. 41 The study by Devanand et al 41 confirmed that impairment in olfactory recognition in a population with normal cognitive function more accurately predicted decline of cognitive function than assessment of verbal episodic memory and supported the cross-cultural application of inexpensive olfactory recognition tests as bio-markers for predicting decline in cognitive function and early stage AD.

Despite the small sample sizes, these combined SNV–CNV subsets demonstrated a highly significant difference in PFS ( p < 0.0001, Fig. 3 ).

Unpaired t-test analysis of the radiance indicated an extremely significant difference (P < 0.0001) between the CD4 CAR and CD4-IL15/IL15sushi CAR groups by Day 14.

qPCR validation of a set of selected targets showed a highly significant correlation with the relative expression levels determined by RNA sequencing (Pearson R = 0.8955; P < 0.0001; Supplementary Figure S9 A).

Kruskal-Wallis analysis revealed a highly significant difference among groups (H = 23.14, p < 0.0001).

An analysis of variance, with sense of closeness as the dependent variable and all nine variables as factors, was highly significant (F 11,17 = 25.89, p < 0.0001).

The mean divergence between VAS and WOMAC weight-bearing pain did not vary significantly with KL grade ( P = 0.72), but a highly significant trend was found for larger mean divergence in VAS and WOMAC non–weight-bearing pain with increasing KL grade ( P < 0.0001) (Figs. 3 A–C). 4.

The difference between the two distributions is highly significant (t > 58, permutation derived P value < 0.0001).

Comparable stomata frequencies were confirmed in the glucose and fructose treatments ( Figure 2B ), and there were highly significant differences with sugar-free conditions ( p -value <0.0001, Mann–Whitney's U-test).

It is also plausible that these inconsistent results are due to the relatively small sample size in MRI studies, as a related clinical study from TREND with a much larger sample size ( N = 661) revealed a highly significant and slightly stronger correlation between TMT B-A and DT gait speed while subtracting ( p < 0.0001, r = 0.27) ( Hobert et al., 2017 ).

Results We find a highly significant positive correlation between Pfirrmann grades and the gene expression of MMP1 (r=0.67, p=0.0001), MMP3 (r=0.61, p=0.0002), MMP10 (r=0.6701, p=0.0001), MMP13 (r=0.48, p=0.004), ADAMTS1 (r=0.67, p=0.0001), and ADAMTS5 (r=0.53, p=0.0017).

The difference between the TRAP-N/CSP-RT (comb) (10/10) and TRAP-N/CSP-T (comb) (0/10) groups was highly significant (p<0.0001, Fisher’s exact test).

The result showed that model of each class diisocyanates was highly significant, with a p -value < 0.0001.

The effects of the study drugs on gut microbiome β-diversity at the OTU level were first tested statistically using a two-way NPMANOVA and the results revealed highly significant main effects for drug (F 4,65 = 3.35; p = 0.0001) and time (F 2,65 = 8.43, p = 0.0001), as well as a significant interaction (F 8,65 = 1.77, p = 0.0001).

The interaction of winter treatment and origin was highly significant (GLMM, X 2 1 = 15.2, P < 0.0001): after warm winters, spiders from the southern core region had higher probability to balloon (18 %) than after cold winters (8%).

(iii) The mean serum level of HE4 in the OvEndo group was 7.6 ng/mL versus 7.8 ng/mL in the CTR group, and we found it highly significant (p=0.0001).

Likewise, there was a highly significant (p<0.0001) reduction in the total number of PCNA foci over the 16-hour timeframe with the average median number of foci only 2351 in HU cells compared to 6125 in controls (Supplementary Figure S4C ).

There was a highly significant difference between the cerebral malaria and meningitis groups ( Figure 1 ) ( P < 0.0001).

Moreover, 8 classes, including CE, CER, DAG, FFA, LPC, PC, SM, and TAG, showed highly significant differentiation with p -values < 0.0001 ( Table 1 ).

Leaf Dip Assay There were no significant differences between insecticide and control treatments at 3 h in the leaf dip assay, although differences were highly significant by 24 h ( p < 0.0001), with mortalities of 70.5% for flupyradifurone and 63.5% for imidacloprid compared to 17.5% for the control ( Figure 3 ).

A highly significant inbreeding coefficient (F = 0.323 ±0.002; p-value<0.0001) was therefore estimated for this group of clones.

This decrease in the DBA was highly significant ( P < 0.0001) ( Fig. 1 ).