Barely Significant

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extremely significantP < 0.00010.0× alphaqualified
* represents P < 0.05, which means the difference is significant; ** represents P < 0.01, which means the difference is very significant; *** represents P < 0.001, which means the difference is extremely significant; **** represents P < 0.0001, which means the difference is more significant than ***; ns means the difference is not significant.
highly significantp < 0.00010.0× alphaqualifiedgold
A generalized additive model (GAM) fitted to the normalized data revealed strong non-linear temporal structure in activity under all light treatments, with highly significant treatment-specific smooths of time (all F > 380, all p < 0.0001), explaining 97.6% of the variance in normalised activity (adjusted R 2 = 0.97).
highly significantP < 0.00010.0× alphaqualifiedgold
Validation and multi-omics characterization of the RSF-based prognostic model Using the RSF-based prognostic model, patients in the TCGA training cohort were stratified into high- and low-risk groups with a highly significant difference in overall survival (P < 0.0001, Figure 4A ).
highly significantp < 0.00010.0× alphaqualifiedgold
Both workflows produced large, highly significant, and quantitatively comparable PC-versus-NC separation under genuine operating conditions (manual: Δ_CI = 0.096 and 0.103; Welch’s t = 19.83 and 21.95; p < 0.0001; Cohen’s d = 1.19 and 1.32; CSA risk scale Δ_P– N = 14.47 with biobank-derived urine-based materials and 10.17 with synthetic VOC standards).