Excerpts

Strikingly, MC903‐treated obese animals had a 68.8% increase in ear thickness after treatment, which was highly significant ( p < 0.0001), compared to lean control animals (29.2% increase) (Figure 4B,C ).

Statistical analysis using an unpaired t ‐test (two‐tailed) confirmed a highly significant difference between the two groups (persister‐state: 0.709 ± 0.375 vs. non‐persister‐state: 1.488 ± 0.619, p < 0.0001).

An analysis of variance on the values of BSS for the locations and factors in the GxExM factorial combination showed that the factor ‘Location’ had a highly significant (p < 0.0001) effect on the BSS (Table 3 , and S1 ).

When the mammary tumor survival data of all homozygous MMTV-BRCA1 and MMTV-BRCA1sv transgenic lines were compared against nontransgenic controls, a highly significant effect on mortality was noted (Fig. 7 A, P<0.0001 for both lines versus nontransgenic controls).

Group category had a highly significant influence on WMS total scores ( p < 0.0001), whereas sex narrowly reached significance level ( p = 0.05).

The difference between the obese ZDF group and the STZ-treated WT group was highly significant ( fa/fa : liver +45%, p < 0.0001; kidney + 64%, p < 0.0001).

For adult life "body weight change" a heritability of 0.15 (highly significant, p < 0.0001) was estimated.

In ULMS, 3 miRNAs—miR-21-5p, miR-27b-3p, and miR-152-3p—had a highly significant underexpression ( p < 0.0001), and 4 miRNAs—miR-129-5p, miR-141-3p, miR-148a-3p, and miR-203a-3p—presented a significant overexpression ( p < 0.0001) (as seen in Figure 3 and Figure 4 ).

The Cochran Armitage test showed a trend towards decreasing CT use for CD overall ( P < 0.0001) and CD induction, ( P = 0.0024).

The two-way ANOVA analyses showed highly significant P at both 5 and 8 months ( P < 0.0001, Fig. 2 ).

Notably, while the unadjusted analysis showed only a borderline association ( P = 0.053), the fully adjusted models revealed a robust and highly significant relationship ( P < 0.0001).

During perifusion of both the whole spinal cord and the cervico-trigeminal area, the interaction between the two factors of variation was found to be highly significant indeed (F 1-27 = 24.33 and F 1-22 = 30.17, respectively, p<0.0001; Table S1 ).

Of the 32 datasets with highly significant changes ( P ≤ 0.0001 and |lineal fold change (FC)| ≥ 2) (Fig. 1a ; Supplementary Table S1 ), 26 (81%) presented higher levels of SMARCA4 transcript in tumor samples than in non-tumor samples.

The ANOVA of the average torque amplitudes of the “ankle,” “hip,” and “upper body” joint groups, revealed highly significant, medium to large main effects ( p < 0.0001) for all three factors ‘beam width’, ‘arm posture’, and ‘joint group’, as well as highly significant ( p < 0.01), small to large interaction effects between these factors (Table 3 ).

Results Exploratory Factor Analysis (EFA) The Kaiser-Meyer-Olkin measure of sampling adequacy index was .74, and Bartlett’s test of sphericity was highly significant, χ 2 = 1076.26, p < .0001, indicating that the sample and correlation matrix were appropriate for exploratory factor analysis (EFA).

Results : The 2-thread VOI yielded a highly significant difference in bone volume fraction (BV/TV) between groups (68.86 ± 4.97% vs. 50 ± 4.32%, p < 0.0001, Cohen’s d = 4.05), while the 5-thread VOI showed no significant difference.

In this comparison, the difference found between the four haploidized strains and the haploid-at-all-times and diploid-at-all-times strains remains highly significant ( t -tests; p < 0.0001).

The difference between these mean changes was highly significant (p < 10 −4 by resampling; Figure S3 A).

* p value < 0.05 was considered statistically significant; ** p value < 0.01 was considered statistically very significant; *** p value < 0.001 was considered statistically extremely significant, and **** p value < 0.0001 was considered statistically highly extremely significant.

The log-rank test indicated highly significant differences in lifespan between control and mutant lines (p < 0.0001).

putrida , P -value < 0.0001; all pairwise tests with element E were highly significant with a P -value < 0.0001, while no other pairs had P < 0.01).

One-way ANOVA for repeated measurements confirmed a highly significant difference between baseline and follow-up within both treatment groups (P < .0001).

Improvements were somewhat lower but highly significant (p<0.0001) in phase 2 (5.4% and 8.7%, respectively; n=62 pulmonologists).

The age difference between the two scan angle groups was highly significant (Mann–Whitney U test, p < 0.0001).

The Kaiser-Meyer-Olkin measure of sampling adequacy was 0.93, and the Bartlett’s test of sphericity was highly significant (χ 2 =1382.51, df=66, p<0.0001).