This highly significant increase (ANOVA, p < 0.0001, followed by a Tukey-Kramer HSD) in the total number of niche cells in the absence of an increase in the number of S phase cells, may also suggest that the 1 st -generation neuronal precursor cells in the crayfish niche are not self-renewing because their numbers can increase without additional cell divisions among the niche cells.
Excerpts
This regression was highly significant (slope = 0.5002, intercept = −0.8805, R 2 = 0.5580, F statistic = 60.59, p < 0.0001; Figure 5F ).
Subsequent validation revealed a highly significant positive correlation ( r = 0.91; p < 0.0001) between RNA-seq and RT-qPCR results indicating a high reliability of the RNA-seq data.
When the herbivory index is bootstrapped for secondarily dominant plant hosts, which are represented by fewer than 100 specimens each, the herbivory index is even more highly variable (electronic supplementary material, figure S1). The difference in leaf surface area between CCP and MCF is highly significant ( p < 0.0001), but is not significant between individual plant hosts from the two localities (electronic supplementary material, table S2; figure S6).
Highly significant differences in the transmission rate (% C Las-positive inoculated leaves) were found between various lines ( Table 6 , P = 0.0001).
There was a highly significant difference in the serum Ki-67 concentrations between healthy dogs and dogs with non-neoplastic diseases ( p < 0.0001, Figure 2 ).
This difference was considered extremely significant (U = 3; U′ = 172, p value < 0.0001). 3.3.
Our results are consistent with those reported elsewhere, indicating reduced low back pain (VAS score) in 75% and reduced disease activity, which is clearly significant during the first 2–3 months and is maintained at ∼6 months according to the VAS score (−3.25, P < 0.0001), BASDAI (−1.86, P < 0.0001) and ASDAS (−1.0, P < 0.0001).
Heat killed parasites failed to induce IFNλ at any timepoint assessed, and at 72 hours post infection, the difference in IFNλ production compared to controls was highly significant ( Fig 3A , p < 0.0001, Two-way ANOVA).
Indeed there was a highly significant ( p < 0.0001) difference between the two with the QTcBZT showing a much greater slope or stronger relationship between QTc and RR interval ( Figure 2(b) ).
This decrease ( Figure 2 ) was highly significant compared to WT ( p < 0.0001) and was not significantly higher than the background switching at time zero ( p > 0.9999).
At T2, the difference between the two groups was highly significant (0 (0–50) copies per 10 3 HPRT1 copies vs 90 (10–190) copies per 10 3 HPRT1 copies, P< 0.0001)) ( Figure 1B ).
Photomicrographic quantitation via pixel counts of images (Figure 1 , panel C) showed that a highly significant (p < 0.0001) increase in collagen content in the treated rat lungs as compared to the control group.
While TBCs + palaeotemperature has been identified as the best model, with a moderately good R 2 value, within this model TBCs is highly significant ( p < 0.0001) but the palaeotemperature proxy is not ( p = 0.76).
The overall multivariate log-rank test was highly significant (chi-squared = 71.16, p < 0.0001), confirming significant differences in conversion-free survival across dose groups.
For the four different carbohydrates, at both time points, for leaves four, five, and six, the differences between sut1 and wild type were highly significant in all cases ( P <0.0001).
The difference in GERD-HRQL before and after RAP was highly significant (absolute reduction 22.3, P < 0.0001, 95 % CI 19.3 – 25.3).
As presented in Table 4 , the model was highly significant ( p < 0.0001) with a non-significant lack of fit ( p = 0.0913).
When the association was analyzed using 500 kb genome windows, a highly significant and positive, but very weak, correlation was found; gene density explained only 3% of the variance in off-target site density ( Figure 2C ; r = 0.17, p < 0.0001). 3.2 Targeted sequencing depth To estimate the coverage depth obtained by the bait-capture targeted sequencing approach at off-target sites, we computed the depth of coverage at pre-filtered variant sites identified by Mutect2 ( Figure 3A ).
However, this tendency was highly significant when considering all the sites (Jost’s combined significance test, p < 0.0001; Table S7 ).
Evaluation of Daratumumab Drug Effect in Immunoglobulin (Ig) G and Non-IgG Myeloma Patients The effect of daratumumab was highly significant in the overall population of patients receiving 16 mg/kg ( p < 0.0001), as well as in patients with IgG ( p < 0.0001) and non-IgG MM ( p = 0.004) [Table 2 ].
Linear regression analysis performed using the Passing-Bablok technique showed that the highly significant relationship between these two variables is given by the quadratic equation NFA FIJI = 2.78 × 10 −4 (NFL) 2 + 0.72(NFL) + 471 (solid curve in Fig. 7 ; p < 0.0001).
Tumor growth curves showed improved tumor control for TILT-517 + anti-PD-1 or anti-PD-L1 compared to their ICIs monotherapy alternatives ( Figures 7 C and 7D), and the combination with anti-PD-L1 displayed highly significant differences ( p < 0.0001).
Not surprisingly, two-way ANOVA showed that both NK1 concentration and injection number were highly significant ( p < 1 × 10 −4 ).
The correlation of F rest with F ref was highly significant (HA 1: Spearman r = 0.92, p < 0.0001; HA 2: Spearman r = 0.84, p < 0.0001) and the regression lines were almost parallel to the bisector, indicating that F rest and F ref were tightly coupled (Fig. 5 ).