Excerpts

The UCP2–CD68 association remained highly significant after adjustment (partial ρ = 0.524, p = 1.80 × 10 − 48 ), confirming that the relationship between UCP2 expression and macrophage infiltration is not a spurious consequence of tumour purity variation ( Supplementary Fig.

The association between α 5 and phalloidin staining was highly significant ( P = 3.32 × 10 −48 ) ( Figure 1(c) , Table 1 ).

In addition, allele frequencies derived from the pooled sequencing experiment were compared to those derived from all individuals in the phase II genotype data and revealed a highly significant correlation (r = 0.971, p < 6.58x10 −48 ), further supporting the validity of the pooled sequencing approach.

When restricted to the 3,137 EUR cases with a PheCode probability >0.80 and their 12,548 matched controls, the 90-SNP weighted PRS was highly significant (odds ratio [OR] = 1.82 [95% confidence interval: 1.68–1.97]; p = 8.0 x 10 −48 ).

A statistical comparison using Cochran's Q test revealed highly significant differences among the models (Q = 235.5, df = 7, p = 3.27E-47).

This 2.76-fold enrichment in this case is highly significant, with a Fisher exact test p = 8.20 × 10 −47 .

With a global average of 52.7% ± 0.12% history-congruent trials, we found a small but highly significant perceptual bias towards preceding experiences ( β = 16.18 ± 1.07, T(1.09×10 3 ) = 15.07, p = 10 −46 ; Fig 2A ) that was largely consistent across studies ( S1B Fig ) and more pronounced in participants who were less sensitive to external sensory information ( S1C Fig ).

The libraries M19 and M25 have 0,985 as correlation coefficient and have a highly significant regression (P = 2,31 × 10 -46 , after Bonferroni correction P = 7,49 × 10 -43 ).

Circulating T cell fraction remained highly significant after adjusting for clinical factors in the pan-cancer cohort (Fig. 5b (HR = 0.76, P = 2.6 × 10 −46 ) and Extended Data Fig. 9a ) and within five individual cancer types after multiple hypothesis correction—head and neck squamous cell carcinoma (HR = 0.70, adjusted P = 4.68 × 10 −2 ), pancreatic adenocarcinoma (HR = 0.74, adjusted P = 4.81 × 10 −2 ), colon adenocarcinoma (HR = 0.85, adjusted P = 1.12 × 10 − 2 ), lung adenocarcinoma (HR = 0.80, adjusted P = 5.4 × 10 −3 ) and sarcoma (HR = 0.68, adjusted P = 1.57 × 10 −4 ).

A highly significant association was observed between BMI and triglyceride levels (Beta = 0.26, p = 3.06E-46), and a positive correlation trend was also seen between BMI and UA.

These represent 41% and 33% of upregulated phosphoproteins in OCMI91s and OVCAR8 cells, respectively - a highly significant overlap by hypergeometric test (enrichment 3.0-fold; p = 4x10 -46 ).

The ANN achieved an F-statistic value of 432.7, indicating a highly significant model fit with a practically negligible probability of F-statistic ( p < 6.06 × 10 −46 ).

5 E) demonstrates highly significant segregation of GBMs and LGGs ( P <10 –45 , odds ratio=28, Fisher exact test) supporting that YAP activation is a hallmark of malignant brain cancer and suggesting that this eight-gene signature might provide sufficient information to distinguish high-grade from low-grade gliomas.

Of note, a highly significant association (− log 10 P = 44.79) for ‘seed: colouration with phenol’ on chromosome 2A was just 0.37 Mb from the Ppo-A1 gene known to control discolouration in wheat food products.

Three transcription factors were highly significant; MYCN (p-value = 1.71E-45), MYC (p-value = 1.11E-11) and NFE2L2 (p-value = 5.97E-17) during this analysis.

Analysis using the GEPIA database revealed a highly significant correlation ( p = 2e -45 , R = 0.82) between these markers, providing new insights into the molecular mechanisms underlying PAAD progression and identifying new targets for diagnostic and therapeutic strategies.

briggsae strains revealed a highly significant effect of both strain ( P = 2.2×10 −45 ) and generation ( P = 5.9×10 −9 ) – see Table 2 .

The paired change was highly significant (McNemar’s χ 2 (1) = 198.89, p < 3.65 × 10 −45 ) ( Figure 4 ).

MMP14 exhibited a marked increase in expression in tumor tissues, with a highly significant difference between normal and cancer groups ( p = 4.9 × 10 −45 ).

Among 11 prototypical sarcomere genes, 10 displayed highly significant isoform shifts (p = 5.23 × 10 −45 –2.89 × 10 −200 ).

A chi‐square test confirmed that this enrichment was highly significant ( p = 1.1357 × 10 −44 ), underscoring the prominent role of DNA transposons in gene regulation.

Another highly significant but non-genic SNP coincides with a selection candidate region (e.g., Figure 3C ) covering the KIT and KDR (P = 2.46e-44) loci.

A highly significant overall association between PRS and COVID-19 infection was shown for the White ethnic group ( p = 8.69 × 10 –44 , < 0.0001).

Subsequent memory effects in selective neurons Due to the preceding screening procedure, we found highly significant fractions of neurons responding selectively to one or more items in all recorded brain regions (all P < 10 –43 , binomial test, one-sided with n = total number of neurons per region, k = number of responsive neurons per region, P = 0.001, corresponding to the alpha level of our response criterion, refer to “item responses”, Fig. 2 , Fig.

A total of 18 SDRs were identified across the genetic maps, primarily located on LG1–LG4, LG6, and LG8, with LG8 and LG3 containing 5 and 4 SDRs respectively, Strong collinearity between the genetic map and physical assembly was confirmed by highly significant Pearson correlations (R = −0.84 to 0.83; P = 10 −43 to 10 −217 ) for marker positions across all nine chromosomes ( Table S9 ; Fig.