Excerpts

The χ 2 test was highly significant for all three pathologists when compared with AFMR scores (p<0.0001) as was the test for a linear-by-linear association (p<0.0001).

Because the social × force × time interaction effect was found to be highly significant ( F (15, 270) = 3.96, p < 0.0001), we subsequently performed separate two-way ANOVAs with two repeated factors (i.e., social condition and target force level) for each 1-s epoch.

The difference between the occupancy levels of these proteins in the two classes of CID boundaries is extremely significant ( Supplementary Figure S6B ; two-sample t -test P -values < 10 −4 in all cases).

As shown in Table 2 , the fitness of the model was highly significant based on the high F -value (227.16) and the very low p -value ( p < 0.0001) [ 20 ].

The relationship for SOC stock was highly significant (R2 = 0.98) with a slope of 1.12 ± 0.06 at p < 0.0001.

Specifically, the Treatment × Time interaction remained highly significant (p < 0.0001), indicating that the treatment effectively slowed tumor growth over time (Table S1).

However, repeating this analysis with every patient in the study population assigned a NF-κB score according to mutation status (which makes use of all study data) and relating this to affected bone numbers, the result was highly significant both when we included all patients (r = 0.277, p < 0.0001) and also when the two patients with A427D mutations were excluded (r = 0.244, p < 0.001) (data not shown). 3.4 Impact of mutations on UBA domain structure and dimerisation We next sought to understand the structural basis of the effects of the I424S and A427D mutants on SQSTM1's ubiquitin-binding function revealed in the pull-down assays ( Fig. 1 b), and in particular, given the close proximity of these mutations to the site affected by the previously characterised G425R mutant, whether common or distinct mechanisms are manifested.

This difference was highly significant, also when correcting for small difference between the sequences at pre-test, t (14) = 5.749, p<0.0001.

A one-way ANOVA demonstrated highly significant differences between treatments for the number of subitaneous eggs (F 5,18 = 30.023, p<0.0001, Fig. 2A ).

Although there was no significant residual difference in the CNV size (p = 0.18) or numbers (p = 0.11) between the mGluR+ and mGluR− groups, there was a highly significant difference in the presence of syndromic features between the mGluR+ and mGluR− groups (p < 0.0001).

Rotational Thromboelastometry Changes between the measuring points (MP1/MP4) were P < .005 for CT INTEM and highly significant ( P < .0001).

Importantly the significance was increasing over the following days of the experiment reaching the highly significant level (p < 0.0001) in the last six days.

We observed a decreasing trend of unintended pregnancy (52.2%-30.2% among non-IDUs, 65.8%-46.0% among IDUs, both P < 0.0001).

Significant factors for the prediction of SVR For the prediction of SVR, factor X 21 (EVR) was highly significant and had a high χ 2 value (p<0.0001; table 3 ).

Given our highly significant results we set the arbitrary voxel-level primary threshold at a more stringent P < 0.0001 for suprathreshold voxels, as is recommended for highly powered studies ( Woo et al., 2014 ).

There was a highly significant interaction with age (p < 0.0001), such that the association was only observed for younger compared with older individuals: HR 1.27 (1.15-1.39) and HR 1.00 (0.92-1.09) in individuals ≤75 years and >75 years, respectively.

Study effect was highly significant in univariate analysis ( P < 0.0001), but no longer in the final model after adjustment of the covariate effects ( P ≥ 0.02).

The ANOVA of the average torque amplitudes of the “ankle,” “hip,” and “upper body” joint groups, revealed highly significant, medium to large main effects ( p < 0.0001) for all three factors ‘beam width’, ‘arm posture’, and ‘joint group’, as well as highly significant ( p < 0.01), small to large interaction effects between these factors (Table 3 ).

Interestingly, for patients with UC, highly significant results concerning vitamin D substitution were only observed in the winter season ( p < 0.0001), whereas in the summer season, the difference was less significant ( p = 0.02).

The Chi-squared test revealed a highly significant variation in prevalence across districts ( χ 2 = 1003·36, P < 0·0001).

Comparison between before 24 weeks gestations and at 37 weeks gestations showed a highly significant decrease (p<0.0001) in fasting blood glucose level.

The ANOVA revealed a highly significant main effect (F = 11.54; p < 0.0001), with an R 2 value of 0.4903, indicating that almost 50% of the observed variability is explained by the model.

At higher doses (25 μ M), Cd data showed clear differentiation starting from time T1, with highly significant differences compared to CTRL ( p ≤ 0.0001 at T1, T2 and T3) ( Fig. 7(b) ).

CCA indicated highly significant (p < 0.0001) time lags of 12 to 72 hours between i . the cyclic fluctuation of an elevated chlorophyll-a signal in the BBL and ii . signals from both the sea surface (occurrence of low atmospheric pressure, wave height (MWH), cooling of surface waters (SST) and the BBL (temperature, tidal signal (pressure), flow-velocity) during the period of investigation (November – May, Table 1 ).

The source of variations genotype and year were significant and the genotype by year interaction was highly significant for both traits (p < 0.0001).