Excerpts

Highly significant ( P < 0.0001) trends of lower prevalence with increasing sibship size were observed in both age groups for a lifetime history of hay fever and for a lifetime history of eczema, with a less significant ( P < 0.001) trend for asthma ever in the adolescents, but not for asthma ever in the younger age group.

The computerized-aided scores showed a moderate to highly significant negative correlation with forced vital capacity (FVC) ( r = −0.490; P < 0.0001), forced expiratory volume in 1 s (FEV1) ( r = −0.675; P < 0.0001) and the single breath carbon monoxide diffusing capacity of the lung (DLco) ( r = −0.653; P < 0.0001) ( Figure 3 ). 3.3.

Analysis of attrition revealed a highly significant divergence, which we have termed the lethal split (x 2 = 27.252, p < 0.0001; Table 1 ): Non-diabetic attrition (n = 52): predominantly attributable to discharge against medical advice (DAMA). 94.2% (n = 49) left against medical advice, and these patients had a low baseline radiological severity (median Rx 0.0).

According to the results obtained, the correlations were highly significant (p < 0.0001).

The F = 221.74 implies that the model is highly significant ( P < 0.0001), that is, there is a chance of only 0.01% of the model occur due to noise, as can be seen in Table 2 .

However, when the subpopulation BAtnV that is also characterized by the highest seroprevalence level of the area, was removed from the analysis, the correlation involving genetic structure became highly significant ( r 2 = 42.6, P = 0.0001) ( Figure 4B ).

In all the mechanical properties tested, a highly significant difference was observed in the mean values between and within the groups ( p < 0.0001).

CKD Stage and Cardiac Biomarkers Concentrations There was a significant trend toward increasing plasma NT-proBNP (P < 0.0001), serum cTnT (P = 0.002), and spot urine albumin creatinine ratio (P < 0.0001) concentrations with declining estimated GFR (eGFR).

Their Pearson correlation analysis showed a highly significant relationship (r = 0.942, p < 0.0001), with no differences between sex genders.

However, repeat siRNA knockdown of CUL5 or HECTD3 caused robust, repeatable, and statistically highly significant (p < 0.0001 in paired t test) stabilization of eYFP-CRAF fluorescence at levels comparable to that obtained with repeat siRNA knockdown of UBE1 ( Figure 2 B).

A two-way ANOVA with factors CT-DBS (pre, active, post) and hemisphere (left, right) showed greater spindle power in the left hemisphere [ F (1) = 6.483, p = 0.0177], as well as a highly significant main effect of CT-DBS condition [ F (2) = 20.411, p < 0.0001] ( Figure 4A , Table 1 ).

Heterogeneity was highly significant ( P < 0.0001).

Overlapping transcripts between MCDD mice and HCC did show a weak and highly significant agreement in direction of transcriptional change (R 2 0.085, P < 0.0001, Figure 6I ).

We observed a highly significant difference between the distance traveled by P-42 and the distance traveled by any of the Aβ monomers, with P < 0.0001 for all three comparisons, respectively ( Fig 2F ).

Dietary phosphate intake and the plasma concentration of 24,25(OH) 2 D were not included in multiple regression because of their highly significant and strong correlation with calcium intake (phosphate intake r = 0.87, P < 0.0001 for countries combined) and plasma 25(OH)D (24,25(OH) 2 D r = 0.94, P < 0.0001 for countries combined), respectively.

The primary endpoint at week 24 showed a highly significant reduction in gadolinium (Gd)-enhancing brain MRI lesions with ocrelizumab treatment vs placebo; the number of Gd-enhancing lesions was 89% ( p < 0.0001) lower in the 600 mg ocrelizumab group than in the placebo group, and 96% ( p < 0.0001) lower in the 2000 mg group [ 3 ].

In this case, the F-statistic is 286.3, with degrees of freedom for the numerator (DFn) as nine and denominator (DFd) as 90, resulting in a highly significant p -value ( p < 0.0001).

The model turned out to be highly significant at the permutation test ( p < 10 −4 ), as shown in Figure 9C , and predictive with 100% correct classification rate. 4 Discussion In the present study, the longitudinal multi-omics investigation on a single mother-infant dyad was proposed to examine in depth the relationships among diet composition, gut microbiota metabolism and composition during the transition from breastfeeding to weaning.

VRS showed an increasing trend with the severity of care, p < 0.0001.

Furthermore, 2.40 MBq 90 Y-DOTA-DAB4 given 24 hours after chemotherapy produced a highly significant extension of MST to 61 days ( P <0.0001 versus control, and P <0.001 versus any other treatment including 2.40 MBq 90 Y-DOTA-7E11 given 24 hours after chemotherapy; Figure 6B ).

In all cases, the differences between phenotype classes were highly significant ( P < 0.0001).

The correlations among the ELM, IS/OS, and COST lengths were extremely significant (all P < 0.0001, Figure 3 ).

The age-adjusted annual incidence ranged from 1.0 per million in 2004 and 2006 to 1.4 per million in 2013; there was an increasing trend in age-adjusted incidence over the entire period ( p <0.0001) but no significant increase during the second half (2010–2016, p = 0.08).

However, the mixture of 10 n m CM4620 and 1 m m galactose provided highly significant protection against BA-elicited necrotic cell death ( P < .0001) as compared to cell death levels in the presence of 10 n m CM4620 alone ( Figure 3A ).

The correlation between the level of expression of gfp-tagged KIR2DL4 and the extent of sHLA-G loading was highly significant ( p ≤ 0.0001).