Excerpts

Moreover, as anticipated, differences between the mean pH values of the n = 6 participants included in this phase of the study were indeed very highly significant ( p = 9.42 × 10 −23 ), with ranges in their mean values being 5.49–6.37.

This difference was highly significant (Wilcoxon rank-sum test, p = 9.46 × 10^-23).

The enrichment for suspected translationally repressed transcripts among the dysregulated proteins of the P clag - cdpk1-gfp was highly significant (p < 10 −22 ).

Statistical validation of these compositional shifts using chi-squared tests revealed highly significant alterations across all comparisons ( p < 10–22), with effect sizes ranging from moderate to very strong (Cramér’s V = 0.29–0.56).

Cuzick’s test for linear trend showed that these median LRS values were linearly related to the T2D status and highly significant ( p < 1.0x10 −22 ).

Both effects remained highly significant after spike rate equalization ( Supplementary Fig. 3b,d online; P < 10 −22 , Wilcoxon signed-rank test, n = 166 neurons from 19 experiments).

Friedman tests consistently ranked FW-CAGIN first (mean rank = 1.0 across all features and datasets; Appendix B , Table B6), with highly significant differences (χ 2 = 73.73–105.21, p < 1.18e−22; Appendix B , Tabke B4).

First, an analysis of expression levels using RNA-seq data from the Maize Gene Atlas [30] reveals a small (∼20%) but highly significant depletion of low-expressed genes (p = 1.30×10 −22 by Mann-Whitney test and ≈0 by Kolmogorov-Smirnov test) ( Fig. 6 ).

Correlation analysis using TCGA database (N = 1,082) across all breast cancer subtypes revealed a highly significant association between ErbB2 and BLVRB expression (ρ = 0.291, p = 1.30 × 10 −22 , Fig. 6 L).

To validate our networks, we determined whether our NBIA-containing modules are composed of the same genes as those in publicly available caudate nucleus networks ( Oldham et al., 2008 ) and identified a highly significant overlap between these two basal ganglia networks (e.g. our brown module vs their M16C module: p = 1.38 × 10 − 22 ; our green module vs their M9C module: p = 2.69 × 10 − 166 ).

This revealed a highly significant relationship between the level of methylation of the CASP1 promoter and CASP1 mRNA expression in ALL cells (p = 1.4 × 10 −22 ; Fig. 1F , Supplementary Fig. 2 panels A–C ).

This overlap is still highly significant, although less striking than in SAT (p = 1.6 × 10 -22 ; Fisher's exact test assuming that 20,000 different genes were tested).

The DML overlap between the two cohorts was highly significant ( p = 1.71 × 10 −22 , 8.17 × 10 −33 and 3.13 × 10 −44 in B cell, memory T cell and Naïve T cells, respectively, by hypergeometric tests).

Educational Resources also presented a highly significant effect ( p = 2.8 × 10 −22 ), with a moderate degree of association between categories ( φ c = 0.439), and the same was true for ESAR Facets ( p = 5.15 × 10 −16 ; φ c = 0.366).

Firstly, there is a highly significant correlation between the measured binding data and the predicted homophilic binding strength (Pearson’s r = 0.86, p ≅ 0 and Spearman’s r = 0.81, p = 3.03e-22, Additional file 2 : Table S3).

The analysis for DtxR cells showed significant downregulation of BChE with a Log 2 FC of −12.3, a highly significant p-value (p = 4.35 × 10 −22 ), and a false discovery rate (FDR) of (8.81 × 10 −21 ).

We detected a highly significant difference (heteroscedastic t -test, t 38 = 20.4, P = 4.5 × 10 −22 ) in estimated copy number between 119S/S (mean ± 95%CI = 4.75 ± 0.32) and 119G/G (mean = 1.12 ± 0.09) individuals (Fig. 5 A).

There was a highly significant difference between geographical locations in both the allele frequency ( X 2 = 127.7, DF = 11, P-value = 4.97x10 -22 ) and frequency of homozygosity ( X 2 = 142.3, DF = 22, P-value = 1.33x10 -19 ).

Relative to the average in syntenic regions, SNPs within ASCs showed a highly significant shift toward lower frequencies ( P = 5 × 10 −22 ) ( Fig. 1C ; Supplemental Note 2), indicating that mutations in ASCs are more deleterious than mutations at random genomic locations.

2014 ) knockout embryos and found a highly significant overlap ( P = 5.9156 × 10 −22 , hypergeometric test) between the genes up-regulated in Ehmt2 −/− and Dnmt3b −/− at E8.5 (Supplemental Fig.

Interestingly however, when compared with the HER2+ subgroup only the Georgia set showed a highly significant increase ( p = 6.00 ×10 -22 ) in MMP7 .

The Figure shows a highly significant correlation between duplicates (R = 0.83, p = 6 × 10 (−22) , Pearson correlation) with a slope of 0.86.

Consistent with this hypothesis, there was a moderately strong, but highly significant, correlation (Spearman rank correlation = 0.47, p < 7.2 x 10 −22 , S5 Fig ) between the ConSurf score for a residue and the median yeast assay score for substitutions at that site, with more conserved residues displaying lower median growth.

The median follow-up for T-DXd was 16.2 months; the median PFS was 6.8 months for the T-DM1 groups, while the median PFS had not been reached for the T-DXd group, with a highly significant difference (HR of 0.28, 0.22-0.37, P = 7.8 × 10 -22 ).

In terms of correlation analysis, the Pearson correlation coefficient was 0.959, demonstrating a very strong positive correlation between ADRRPs and phoropter measurements ( p = 8.13 × 10 − 22 , highly significant), while the Spearman correlation coefficient was 0.878, also indicating a strong positive correlation ( p = 2.03 × 10 − 1 3 , highly significant).