Excerpts

A chi‐squared test between treatment groups and gel categorization scores found a highly significant association between these two categorical variables (chi‐square test, p ‐value = 6.53 × 10 −24 , Figure 6 ).

While rs2647044 ( P = 3.85×10 −20 ) was still highly significant, rs9357152 ( P = 7.28×10 −24 ) became the most significantly associated SNP when the effects from the known HLA high-risk genotypes were accounted for in the logistic regression model.

Ingenuity pathway analysis identified highly significant overrepresentation of several pathways, including oxidative phosphorylation (OXPHOS; p = 8.1 × 10 −24 ) and mTOR signaling (p = 8.5 × 10 −10 ) ( Figure 5 C).

For example, when distinguishing individuals with MCI from those with CN, CR-Proxy showed a highly significant difference ( p = 8.14 × 10 − 24 , Cohen’s d = 0.68 ), compared to Brain-PAD ( p = 6.93 × 10 − 4 , d = − 0.25 ).

Together they form a highly significant reaction set (P < 10 -23 for each of the three possible reaction pairs), whose congruence in genomic association is nearly perfect.

In the ser2 Δ background strains, one‐way ANOVA identified highly significant differences among plasmid constructs ( P < 10 −23 ), and Tukey's HSD post hoc test resolved distinct complementation groups.

Consistent with Lirnet's predictions, we observed a modest but highly significant down-regulation (KS p-value<10 −23 ) of the Puf3 module in the RM mkt1Δ strain ( Figure 8C ).

This difference was highly significant, reflecting a strong main effect of stimulus type on mean RT ( F (1,108) = 167.01, p = 1e‐23), and remained significant within both HCs ( t (36) = 9.84, p = 9e‐12) and PwMS ( t (72) = 10.05, p = 2e‐15).

For Abpa paralogues (Figure 6A ), we were unable to detect strong evidence of positive selection: M1/M2 test did not show evidence of selection (P > 0.25), while the M7/M8 test was highly significant (P < 10 -23 ).

Summarizing the results to this point, the genome-wide association study revealed a highly significant association in the vicinity of Lgi2 , an extremely strong association (p = 1.05×10 −23 ) with the protein-truncating c.1552A>T (p.K518X) sequence change in the gene, and no significant association with any other locus.

The results were highly significant: p = 1.11 × 10 −23 ( Fig 3A ); p = 5.29 × 10 −16 ( Fig 3B ); p = 3.88 × 10 −5 ( Fig 3D ); p = 1.38 × 10 −16 ( Fig 3E ); p = 1.00 × 10 −9 ( Fig 3F ).

Calculating the probability of observing this increase by chance according to the hypergeometric distribution indicates that this increase is highly significant ( P = 1.12E–23).

For AUROC, the test showed highly significant differences ( χ 2 = 128.06, df = 6, P = 1.23 × 10 −23 ).

Indeed, 72 of the pivots were found to be essential, a highly significant fraction given the total number of essential genes in the network (22.6 essentials expected, P =1.42 × 10 −23 ).

Overall, there is a highly significant negative correlation (Spearman rank = -0.16, p = 1.6E-23) clearly demonstrating that larger proteins tend be less abundant than smaller proteins.

A two-way ANOVA conducted across both cell lines demonstrated a highly significant main effect of drug concentration (F(1,80) = 199.32, p < 1.99e − 23), a significant interaction between formulation and concentration (F(3,80) = 8.01, p < 9.89e − 05), and a significant main effect of formulation type (F(3,80) = 4.08, p = 0.0095), indicating that cytotoxicity is concentration-dependent and formulation-specific, with more pronounced differences observed at higher doses.

Differences across quartiles were highly significant (global χ 2 p=2.3×10−23), reflecting clear enrichment of PRS benefit in individuals with greater genetic predisposition.

The Friedman test confirmed highly significant differences among the algorithms ( χ 2 = 121.98 , p = 2.96 × 10 − 23 ), justifying a detailed pairwise analysis.

47 The most recent GWAS for JT and QT intervals found highly significant associations, respectively, with rs17171731 ( P = 4E-23) and rs1335516 ( P = 1E-43, in very high LD with each other in European ancestry populations), with the AF risk allele associated with longer durations. 48 The GTEx project shows relatively low expression of FAM13B in human left ventricle (median value 5.5 transcripts per million), and no significant left ventricle FAM13B eQTLs are detected.

Previous reports have implicated deleterious coding variants in IFIH1 , the third member of the RLR family, as conferring protection against psoriasis 8 , 71 and psoriatic arthritis 72 ; the protective IFIH1 variants rs35667974 and rs1990760 are both highly significant in the current meta-analysis ( P = 5.0 × 10 −23 and 7.0 × 10 −50 , respectively) but not prioritised in credible sets due to insufficient effective sample size and the presence of a more strongly associated intronic variant (rs2111485), respectively.

7C ), of which 558, or 90.6%, a highly significant proportion ( P = 6 × 10 −23 , hypergeometric test), were associated with OLIG2 binding sites within one or more of the CREs defined in this study, suggesting that OLIG2 acts as a transcriptional activator for some of its functions in NS cells.

S3), as well as a highly significant negative genetic correlation between c-intensity and age at menarche (rg = − 0.52, P = 6.72 × 10 −23 ), indicating that genetic determinants of later pubertal onset also favor a slower tempo of growth.

While increasing the pull speed slightly reduces the modulus of the baseline APA (estimate −223.7, p = 0.0472), the massive and highly significant interaction term (estimate 4015, p = 7.04 × 10 −23 ) reveals that combining high draw speeds with high LCP concentrations dramatically increases the overall stiffness of the extrudate.

When comparing these two gene lists we observed extensive overlap (N = 263) that was calculated to be highly significant (p < 7.130e-23)( Supplementary Table S1 ).

Survival analysis confirmed the highly significant impact of IL-6 (P = 8.56e−23) on the survival of COVID-19 patients and also identified a nominally significant effect of IL-2R on survival (P = 0.0003, Figure S1 , Table S1 ).