Excerpts

2 inset), a highly significant difference (p = 8.62×10 −22 , Fisher's exact test) suggesting that introducing the epigenetic mechanism enabled networks to evolve a strongly increased capacity for adding new input/output states.

This pair is highly significant based on all 5 DPA methods as well as the OffSides database (rr= 2.75000000015865, p value < 8.67518006759968e-22).

371 of these were within a central cluster representing highly significant overlap (p<1e-21; 1.55-fold enrichment).

Results With all possible fMRI contrast parameters, the three-factor models were highly significant ( p < 1.0 x 10 -21 ).

The enrichment of class M in cluster III is statistically highly significant ( p -value = 10 -21 ).

Highly significant associations for a nonsynonymous SNP (rs12075; G42D ( NP_002027.2 ) ( p = 1.3E-21) and an intronic SNP ( p = 3.6E-13) in DARC on chromosome 1 were identified for MCP-1.

The difference between CTA and all genes was highly significant with Mann–Whitney U test p -value = 1.47E-21, and likewise for CTX versus all genes with p -value = 1.16E-23.

MR analysis in the same study provided further highly significant evidence of a causal relationship between mLOY and AF (HR: 1.15, 95% CI: 1.13–1.18, p = 1.52 × 10 −21 ).

This overrepresentation of prophage DNA is highly significant (binomial test, P = 3 × 10 −21 ).

Furthermore, there was however a strong trend in CPD across age groups; cases in the uppermost quantile having a cigarette consumption of 3.2 CPD less than those in the lowest age quantile ( P = 3.01×10 −21 ).

The mean ΔPPD ( ± SE) for the bTB+ animal group was 1170.35 ± 84.48 compared to −360.46 ± 55.17 for the bTB− group and this group difference was highly significant (two-tailed Wilcoxon rank-sum test; P < 3.258 × 10 −21 ) (Supplementary Fig.

In monocytes, highly significant enrichment was observed for regulation of inflammatory response (GO:0050727, p = 3.95 × 10 −21 ), positive regulation of innate immune response (GO:0045089, p = 2.69 × 10 −18 ), the innate immune response-activating signaling pathway (GO:0002758, p = 2.69 × 10 −16 ), canonical NF-kappaB signal transduction (GO:0007249, p = 3.00 × 10 −9 ), and the tumor necrosis factor-mediated signaling pathway (GO:0033209, p = 0.001).

We observed a highly significant correlation between the signature count score and ME in the Test dataset (OR = 1.23 per standard deviation increase, p = 4 × 10 − 21 ) when including sex and the top 10 genetic principal components as confounders in the logistic regression.

This SNP was also highly significant in our analysis ( p = 5.4 × 10 −21 , beta = 0.27 years, effective-allele = G).

Finally, Fbp1 had a highly significant cis eQTL (rs13481847; P =6.1×10 −21 ) in the cochlea that maps ∼100 kb upstream of our peak GWAS SNP on chromosome 13 for ABR threshold after a 24-kHz tone burst.

Discussion The BCO2 mutation ( c.196C>T ) identified in the present study showed a highly significant (P = 7. 44 × 10 -21 ) association with yellow adipose tissue in 428 genotyped sheep.

The ciliary modules were found to share on average more than 50% of genes with each other, this overlap statistically highly significant (P<10 −20 for the least significant pair of the datasets; see Table S4 for details on the cross-dataset overlap of the modules).

Moreover, the overlap between the hyper- and hypo-methylated ESSEs in the Jurkat cells and DLBCL samples was highly significant ( p-value < 1E-20) (top panels, Fig 8B ).

Still, for the remaining animals, the differences in the number of detected SNPs were highly significant ( P < 10 −20 ).

This effect is strongest for the pairwise deviation between means (61% reduction), but also highly significant for the other measures ( P < 10 −20 in all cases).

The overlap of Arc-dVenus -enriched genes with activity-regulated and visual stimulus-induced genes is highly significant (each p < 10 −20 , hypergeometric test) ( Fig. 3C,D ).

While the prediction of these algorithms was far from being perfect for each individual RNAi trigger, we found a highly significant correlation (Pearson = 90.6%, p < 10 −20 ) between this algorithm’s scores and our average screen score.

Two-by-two χ 2 tests comparing each mutant to ndt80 Δ at the same threshold confirmed that all contrasts were highly significant (χ 2 = 86.7–197.2, df = 1, p < 10 −20 ; full statistics in Table S2 ).

As further confirmation of the quality of the model, analysis of variance of cross-validated residuals (CV-ANOVA) for the PLS-DA model was highly significant (p<1x10 -20 ).

The three large duplications in wMelPop, wMel2_a and wMel2_b were highly significant (t tests: p <10 −20 ).