There was a highly significant correlation between plasma exposure of MIV-711 and effects on bone resorption ( p < 0.0001, Pearson correlation, r 2 = 0.71).
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Although in this extended set marker rs3805663 did not reach a significant p-value any more, several additional markers showed highly significant results with the most significant result for rs6596189 (p = 1 * 10 -4 ).
When compared to the illness control, the memory-enhancing potential of novel N -benzyl pyridine-2-one derivatives was highly significant (P < 0.0001).
A highly significant difference ( P = 0.0001) was observed compared to those receiving placebo ( N = 57) who maintained their mean BMD at the lumbar spine over 5 years of follow-up (−0.1% (95% CI -1.3 to 1.0)).
The comparative statistical analysis using one-way ANOVA indicated that there were highly significant interspecies cytotoxic activity differences (**** p < 0.0001), while on the other hand only a few comparisons didn’t show any significant difference (ns) (Fig. 4 ).
• HER2 status and HER2/CEP17 ratio: A highly significant association was found (P = 0.0001).
The mean serum CA-125 level was markedly elevated in the endometriosis group (51.9 ± 9.5 U/mL) compared to controls (16.0 ± 8.0 U/mL), showing a highly significant difference ( P < 0.0001).
The model is highly significant ( p < 0.0001), showing that it effectively explains the variation in TC.
One-way ANOVA confirmed these differences were highly significant (F = 76.79, p < 0.0001).
Statistical analyses were performed with Student’s t-test, with p -value reported as * p < 0.05 considered statistically significant, ** p < 0.01 considered highly significant and *** p < 0.0001 very highly significant.
For the KEGG 3+DB signalling pathways network betweenness centrality – a measure of the difference between the node with the highest betweenness centrality (the node on the most shortest paths) to all other nodes in the network – we did see a small trend towards pathway networks having lower betweenness centrality (p<0.0001 (WNT pathway) to p<0.837 (VEGF pathway).
The difference is highly significant (t(11) = 8.5, p = 0.0001).
On the other hand, assessment of the association between the different pathobiological factors showed a highly significant association of cyclin E with p21 expression ( P <0.0001) and with p53 ( P =0.014).
The results showed that the model of K extraction recovery was highly significant, with F value = 47.06 and p -value < 0.0001.
For all outlet types, deprivation is a highly significant ( p < 0.0001) predictor of both baseline outlet density and of changes in density over time.
Among all the sites where a positive drug–diet interaction was found, the CeA was most highly significant (* p < 0.0001).
The statistical evaluation of compressive strength results, using one-way ANOVA ( Table 7 ), showed a highly significant effect of the mixture composition on mechanical performance (F = 28.83, p < 0.0001).
The pattern of distribution for NM and M trials is almost mirror reversed, and consequently there is a highly significant difference when comparing the amount of original and reversed position trials for NM and M trials (χ 2 1 = 126.0, p<.0001, φ = .75).
The p -value was highly significant ( p < 0.0001) and the lack-of-fit p -values were larger than 0.05 (0.1673, 0.6943, and 0.7078, respectively).
A highly significant correlation between IGF-1 and IGFBP-3 on a molar basis ( r = 0.84; P < 0.0001) has been revealed.
Comparison of D7r2 and D7r4 expression in these individuals revealed a highly significant correlation (Spearman r = 0.9075, p < 0.0001), which supports the hypothesis that these genes are co-regulated.
Target density, cull capacity, and cull radius were highly significant main effects by county, culled animals, culled farms, and epidemic length according to Type I and Type III analyses of likelihood ratios ( χ 2 , P < 0.0001).
4 , the overall effect of ondansetron was a reduction of the R+V by about 70% (−0.69, −0.82 to −0.55) and this was highly significant ( Z = 10.05, P < 0.0001).
Species was also highly significant ( P < 0.0001; Table 1 ), with fir having an earlier phenology than spruce, with a mean difference of about 6 d between species.
One-year survival for good, moderate, and poor risk groups were 48.5, 25.7, and 11%, respectively, with a highly significant difference among the three groups ( P <0.0001).